Development and characterization of mucoadhesive system for administration of colon-specific drugs

• Grant number: 12/20500-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2013
• End date: July 31, 2013
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Maria Palmira Daflon Gremião
• Grantee: Thais Emboaba de Oliveira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis are common and their treatment is often difficult due to the presence of mucus, which can be a barrier to the permanence of the drug at this place. One alternative for improving the treatment of these diseases is the use of mucoadhesive systems that can target and enhance the release of the drug in the mucosa of the gastrointestinal tract. Polymers such as poloxamers and derivatives of polyacrylic acid (PAA) are widely used in mucoadhesive delivery systems, may act in several ways, among them by increasing the viscosity of the system by varying pH or temperature. The aim of this work is to develop and characterize mucoadhesive systems for the delivery of colon-specific drugs. In this context, it will be developed hydrogels composed of in situ gelling stimuli-sensitive polymers. It will be done physicochemical characterization of these systems, besides the incorporation of the model drug (5-ASA) and the release test of this drug.(AU)