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Cardiorespiratory, sedatives and antinociceptives effects of the detomidine in combination with lidocaine on caudal epidural anesthesia in horses

Grant number: 12/23476-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2013
Effective date (End): August 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Ewaldo de Mattos Junior
Grantee:Eduardo Henrique de Castro Rezende
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

With the objective verify the cardiorespiratory, sedative and antinociceptive effects of dexmedetomidine combined with lidocaine in horses, will be used six animals, male or female, and clinically healthy. They will be randomly assigned to three groups of six animals in blinded crossover study, with minimum interval of 7 days between treatments. The groups are designated as D (dexmedetomidine 3.5 microg/kg), DL (dexmedetomidine 3.5 microg/kg + 0.2 mg/kg lidocaine) and L (0.2 mg/kg lidocaine). The drugs will be applied with the aid of epidural catheter inserted into the coccygeal space. Will be assessed values of heart rate and respiratory rate, systolic, mean and diastolic blood pressure, rectal temperature, hydrogen potential in arterial blood (pHa), partial pressure of oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2), arterial oxygen saturation (SaO2), bicarbonate (HCO3-), base deficit (DEB), sedation and antinociceptive aspects. The data are evaluated in the moments M0 to M480, M0 corresponding to basal, 15, 30, 60, 120, 240 and 480 minutes after drug administration, a total of eight hours of evaluation. The results will be tested using the Shapiro-Wilk normality test; when data present normal distribution will be employed analysis of variance (ANOVA) with repeated measures and Bonferroni's test complementary analysis and variables with anormal distribution will be compared with the Wilcoxon test. The significance level is 5%.