Effect of prior parenteral use of omega-3 and glutamine isolated and combined submitted the systemic inflammatory response and mortality in experimental acute pancreatitis

• Grant number: 12/13691-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2013
• End date: August 14, 2015
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Dan Linetzky Waitzberg
• Grantee: Priscila Casarin Garla
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 13/25796-2 - Analysis of lipid mediators prostaglandin PGE2, TXB2 thromboxane, leukotrienes LTB4, lipoxin A4 and resolvin E1 in rat lung after parenteral infusion of omega-3 lipid emulsion after 12 and 24 hours of induction of severe acute pancreatitis, BE.EP.MS

Abstract

In clinical practice the combined use of parenteral glutamine and omega-3 (AG n-3) may be used in severe critically ill patients for modulating the immune, metabolic and inflammatory response. However, there are not enough data to indicate the efficacy and safety of the combined use of parenteral glutamine and omega-3 fatty acids in conditions of metabolic stress. Our goal is, in an experimental model of acute pancreatitis in rats, to study the effect of the isolated and combined use of parenteral glutamine and omega-3 lipid emulsion on the systemic inflammatory response biomarkers and mortality. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GARLA, Priscila Casarin. Impact of prior use of parenteral fish oil lipid emulsion in thesystemic inflammatory response and survival in an experimental model of acutepancreatitis. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.