Changes in the thymic microenvironment during the acute phase of experimental infection with Paracoccidioides brasiliensis

• Grant number: 13/01401-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2013
• End date: July 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Liana Maria Cardoso Verinaud
• Grantee: Rosária Di Gangi
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The primary lymphoid organ responsible for maturation of T cells (or thymocytes, while the thymus) is the thymus, the microenvironment is composed of cellular elements and soluble precursors responsible for the migration of T lymphocytes into the perivascular space and subsequent cortical region migration to the spinal region. The integrity of the thymic microenvironment is critical for differentiation, maturation and thymocyte development, mature lymphocytes making them ready to migrate to the secondary lymphoid organs. The literature shows that changes in the thymic microenvironment may occur as a result of some pathologies. Studies in murine models of thymic atrophy point thymus as target organ of various parasitic infections, viral, helminthic and fungal infections, and even metabolic disorders. In these studies, such as in studies by our group, we observed strong affection thymic involution with organ derangement accompanied by the thymic architecture and depletion of the subpopulations of thymocytes. This work aims to expand in the first stage data on thymic changes observed in early infection Pb and, in a second step, to evaluate a possible functional recovery of the body after the early phase of infection.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA COSTA, THIAGO ALVES; DI GANGI, ROSARIA; MARTINS, PAULA; FIGUEIREDO LONGHINI, ANA LEDA; ZANUCOLI, FABIO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE; STACH-MACHADO, DAGMAR RUTH; BURGER, EVA; VERINAUD, LIANA; THOME, RODOLFO. Protection against Paracoccidioides brasiliensis infection in mice treated with modulated dendritic cells relies on inhibition of interleukin-10 production by CD8(+) T cells. Immunology, v. 146, n. 3, p. 486-495, NOV 2015. (13/08194-9, 12/22131-7, 13/01401-9, 11/17965-3, 14/02631-0)

DI GANGI, ROSARIA; DA COSTA, THIAGO ALVES; THOME, RODOLFO; PERON, GABRIELA; BURGER, EVA; VERINAUD, LIANA. Paracoccidioides brasiliensis infection promotes thymic disarrangement and premature egress of mature lymphocytes expressing prohibitive TCRs. BMC INFECTIOUS DISEASES, v. 16, MAY 17 2016. (12/22131-7, 13/01401-9, 13/08194-9, 14/02631-0)

DA COSTA, THIAGO ALVES; DI GANGI, ROSARIA; THOME, RODOLFO; FELISBINO, MARINA BARRETO; BONFANTI, AMANDA PIRES; WATANABE ISHIKAWA, LARISSA LUMI; SARTORI, ALEXANDRINA; BURGER, EVA; VERINAUD, LIANA. Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. PLoS One, v. 11, n. 10, OCT 13 2016. (14/19492-3, 13/08194-9, 12/03238-5, 12/22131-7, 13/01401-9, 14/02631-0)

THOME, RODOLFO; ISSAYAMA, LUIDY K.; DA COSTA, THIAGO ALVES; GANGI, ROSARIA D.; FERREIRA, ISADORA T.; RAPOSO, CATARINA; LOPES, STEFANIE C. P.; DA CRUZ HOEFLING, MARIA ALICE; COSTA, FABIO T. M.; VERINAUD, LIANA. Dendritic cells treated with crude Plasmodium berghei extracts acquire immune-modulatory properties and suppress the development of autoimmune neuroinflammation. Immunology, v. 143, n. 2, p. 164-173, OCT 2014. (12/22131-7, 13/01401-9, 11/13191-3, 11/17965-3)

THOME, RODOLFO; ISSAYAMA, LUIDY K.; DA COSTA, THIAGO ALVES; GANGI, ROSARIA D.; FERREIRA, ISADORA T.; RAPOSO, CATARINA; LOPES, STEFANIE C. P.; DA CRUZ HOEFLING, MARIA ALICE; COSTA, FABIO T. M.; VERINAUD, LIANA. Dendritic cells treated with crude Plasmodium berghei extracts acquire immune-modulatory properties and suppress the development of autoimmune neuroinflammation. IMMUNOLOGY, v. 143, n. 2, p. 10-pg., 2014-10-01. (13/01401-9, 11/13191-3, 12/22131-7, 11/17965-3)

DA COSTA, THIAGO ALVES; DI GANGI, ROSARIA; MARTINS, PAULA; FIGUEIREDO LONGHINI, ANA LEDA; ZANUCOLI, FABIO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE; STACH-MACHADO, DAGMAR RUTH; BURGER, EVA; VERINAUD, LIANA; THOME, RODOLFO. Protection against Paracoccidioides brasiliensis infection in mice treated with modulated dendritic cells relies on inhibition of interleukin-10 production by CD8(+) T cells. IMMUNOLOGY, v. 146, n. 3, p. 10-pg., 2015-11-01. (13/01401-9, 12/22131-7, 13/08194-9, 14/02631-0, 11/17965-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GANGI, Rosária Di. Changes in thymic microenvironment during the acute phase of experimental infection with Paracoccidioides brasiliensis. 2015. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.