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Evaluation of paracoccin interaction with cell receptors of innate immunity, in order to determine its role in the acute phase of paracoccidioidomycosis

Grant number: 10/01112-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2010
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Maria Cristina Roque Antunes Barreira
Grantee:Ana Claudia Paiva Alegre
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Paracoccidioides brasiliensis is the etiological agent of Paracoccidioidomycosis (PCM), mycosis most prevalent in Latin America, focusing on an area ranging from Mexico to Argentina, the highest incidence in Brazil, Venezuela and Colombia. The spectrum of PCM ranges from benign and localized to widespread and severe forms of the disease, often lethal. The acute form affects young patients of both sexes, mainly involving the reticuloendothelial system. Meanwhile, the chronic form is prevalent in adult males with predominantly pulmonary involvement and / or mucocutaneous, and is frequently fatal. Among the factors themselves of the fungus able to increase its pathogenicity are mentioned lipids, polysaccharides and glycoproteins. A lectin from P. brasiliensis called paracoccin (70 kDa) with affinity for N-acetyl glucosamine, was identified and located on the cell surface. This lectin contributes to the adherence of the fungus to extracellular matrix, inducing macrophage to produce TNF-alpha and high concentrations of NO. These characteristics justify the investment of effort to evaluate the interaction of paracoccin with cell receptors of innate immunity, in order to determine its role in the acute phase of paracoccidioidomycosis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAIVA ALEGRE-MALLER, ANA CLAUDIA; MENDONCA, FLAVIA COSTA; DA SILVA, THIAGO APARECIDO; OLIVEIRA, ALINE FERREIRA; FREITAS, MATEUS SILVEIRA; HANNA, EBERT SEIXAS; ALMEIDA, IGOR C.; GAY, NICHOLAS J.; ROQUE-BARREIRA, MARIA CRISTINA. Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs. PLoS Neglected Tropical Diseases, v. 8, n. 12 DEC 2014. Web of Science Citations: 17.
PAIVA ALEGRE, ANA CLAUDIA; OLIVEIRA, ALINE FERREIRA; DOS REIS ALMEIDA, FAUSTO BRUNO; ROQUE-BARREIRA, MARIA CRISTINA; HANNA, EBERT SEIXAS. Recombinant Paracoccin Reproduces the Biological Properties of the Native Protein and Induces Protective Th1 Immunity against Paracoccidioides brasiliensis Infection. PLoS Neglected Tropical Diseases, v. 8, n. 4 APR 2014. Web of Science Citations: 17.

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Filed patent(s) as a result of this research project

POLIPEPTÍDIO RECOMBINANTE, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO UM POLIPEPTÍDIO RECOMBINANTE E MÉTODO DE TRATAMENTO. BR1020150030177 - Universidade de São Paulo (USP) . Aline Ferreira De Oliveira Pereira; Maria Cristina Roque Antunes Barreira; Ebert Seixas Hanna; Fausto Bruno Dos Reis Almeida; Ana Claudia Paiva Alegre Maller - February 2015, 11