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Investigation of correlations between metabolic syndrome and dry eye and ocular surface changes

Grant number: 12/22371-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2013
Effective date (End): March 31, 2014
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Eduardo Melani Rocha
Grantee:Jacqueline Ferreira Faustino
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Metabolic syndrome (MS) is characterized by the association of type 2 diabetes mellitus or glucose intolerance, obesity, hypertension and dyslipidemia. These changes receive treatment recommendation with various medications. And these conditions were previously linked independently to dry eye syndrome. The aim of this study is to investigate the association between MS and dry eye syndrome.For this we designed a cross-sectional study in which 20 patients with MS and 20 healthy volunteers will be evaluated for ocular discomfort, fluorescein staining and lisamina green time of tear film breakup (TRFL), Schirmer test without anesthetic test osmolarity,. Since these same patients are evaluated for their body composition by measuring triceps, weight, height, waist circumference, and BMI.The evaluation will yield comparatively confirm the change, as well as through correlations between findings, observe potential pathophysiological mechanisms.