ISOLATION AND ESTRUCTURAL CHARACTERTHERIZATION OF NOVEL COMPOUNDS WITH POTENCIAL THERAPEUTIC APPLICATION FROM BRAZILIAN FRESHWATER CYANOBACTERIA

• Grant number: 12/25272-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2013
• End date: August 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ernani Pinto Junior
• Grantee: Miriam Sanz Roldán
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Cyanobacterias biosynthase a great variety of secondary metabolites with a wide range of bioactivities. Although initially, toxins would be the metabolites that mainly attracted the attention of researchers all over the world, nowadays the amount of novel compounds with potential therapeutic application isolated from these microorganisms is continuously increasing. In this study, various species of freshwater cyanobacteria autochthonous from Brazil (Microcystis sp., Pseudoanabaena sp., Oscillatoria sp., Sphaerospermopsis torques-reginae e Cylindrospermopsis sp.) will be screened for the presence of novel compounds with potential biomedical application. For this purpose, bioassay-guided isolation methods will be developed and novel compounds will be fully characterized and their bioactivities will be established.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANZ, MIRIAM; DOERR, FELIPE AUGUSTO; PINTO, ERNANI. First report of spumigin production by the toxic Sphaerospermopsis torques-reginae cyanobacterium. Toxicon, v. 108, p. 15-18, DEC 15 2015. (14/50420-9, 12/25272-0, 11/51950-3)

SANZ, MIRIAM; DINI ANDREOTE, ANA PAULA; FIORE, MARLI FATIMA; DOERR, FELIPE AUGUSTO; PINTO, ERNANI. Structural Characterization of New Peptide Variants Produced by Cyanobacteria from the Brazilian Atlantic Coastal Forest Using Liquid Chromatography Coupled to Quadrupole Time-of-Flight Tandem Mass Spectrometry. MARINE DRUGS, v. 13, n. 6, p. 3892-3919, JUN 2015. (12/25272-0, 09/15402-1, 13/09192-0, 11/51950-3)

LIMA, STELLA T.; ALYARENGA, DANILLO.; ETCHEGARAY, AUGUSTO; FEWER, DAVID P.; JOKELA, JOUNI; VARANI, ALESSANDRO M.; SANZ, MIRIAM; DORR, FELIPE A.; PINTO, ERNANI; SIYONEN, KAARINA; et al. Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torquesreginae ITEP-024. ACS Chemical Biology, v. 12, n. 3, p. 769-778, MAR 2017. (12/25272-0, 14/50420-9, 11/08092-6, 13/50425-8)

SANZ, MIRIAM; SALINAS, ROBERTO KOPKE; PINTO, ERNANI. Namalides B and C and Spumigins K-N from the Cultured Freshwater Cyanobacterium Sphaerospermopsis torques-reginae. Journal of Natural Products, v. 80, n. 9, p. 2492-2501, SEP 2017. (14/50420-9, 12/25272-0, 16/07490-1)