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Synthetic Studies Aiming the Preparation of alpha amino acids with Potential Biological Activity

Grant number: 13/01388-2
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2013
Effective date (End): January 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Giuliano Cesar Clososki
Grantee:Leandro Alves Bozzini
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Modern organometallic reagents such as the turbo Grignard i-PrMgCl.LiCl have been successfully applied in the preparation of functionalized aromatic and heterocyclic compounds. However, their application to the preparation of substances of great medical interest, such as alpha amino acids, has not been properly studied . Thus, the main objective of this project is to investigate the enantioselective preparation of alpha amino acids from the reaction of optically active aziridines with aromatic organomagnesium reagents of the type ArMgCl.LiCl

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BOZZINI, Leandro Alves. Synthetic studies aimed at preparation of caramboxina, an alpha-amino acid with potential biological activity.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Ribeirão Preto.

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