Pathogenicity studies of the Brazilian variant strain (BR) of infectious bronchitis virus

• Grant number: 13/02058-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2013
• End date: February 28, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Clarice Weis Arns
• Grantee: Leonardo Cardia Caserta
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Recent studies identified variants of the Infectious bronchitis vírus (IBV) exclusives from Brazil (BR), which genotype is not related to the Massachussets serotype. In Brazil, alive vaccines for IBV are only allowed if belonging to this serotype, what suggests an inefficient protection against brazilian variants. Due to the lack of studies focusing the pathogenicity of the BR variant of IBV, the knowledge of its effects becomes necessary, elucidating clinical signs, macroscopic and microscopic lesions, besides the immunity against this virus. This study aims to analyse the pathogenicity and tropism of the BR variant of IBV for poultries through a in vivo experiment, using specific pathogen free (SPF) birds. The observation of clinical signs, besides serology, histopathology and real time RT-PCR of the organs samples will be the techniques chosen to assess the immune response, lesions and to quantificate the viral RNA, defining then the tropism of this variant.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CASERTA, Leonardo Cardia. Pathogenicity studies of the brazilian variant strain (BR) of infectious bronchitis virus. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.