Possible interaction between endocannabinoid, glutamatergic and nitrergic systems of the CPFmv in modulation of emotional / behavioral consequences to stress.

• Grant number: 13/00279-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2013
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Sâmia Regiane Lourenço Joca
• Grantee: Ariandra Guerini Sartim
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Endocannabinoids are endogenous agonists of CB1 receptors that are also able to activate TRPV1 receptors when administered in high doses. Such profile may explain the biphasic responses observed in animal models, with compounds that act in the endocannabinoid system. In the forced swim test, CB1 agonists show potential antidepressant-like effect when administered in the ventral medial prefrontal cortex (CPFmv). However, the involvement of TRPV1 receptors in behavioral responses related to depression has been little investigated. In addition to CB1 agonists, NMDA receptors antagonists or inhibitors of NO synthesis, also promote antidepressant-like effect when administered in CPFmv. Activation of CB1 receptors decreases glutamatergic neurotransmission in different brain structures related to emotional control, whereas the activation of TRPV1 receptors increases the levels of glutamate and NO in these structures. In this sense, it is known that the endocannabinoid, glutamatergic and nitrergic systems interact to generate differents behavioral responses. However, little is known about the effects of this interaction on mood disorders such as depression. Therefore, the present study aims to investigate the role of CB1 and TRPV1 in antidepressant-like effect of anandamide, an endocannabinoid, in CPFmv. Moreover, it aims to assess the possible interaction between the endocannabinoid, glutamatergic and nitrergic systems of CPFmv in the modulation of behavioral consequences to stress.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SARTIM, A. G.; SARTIM, M. A.; CUMMINGS, R. D.; DIAS-BARUFFI, M.; JOCA, S. R.. Impaired emotional response to stress in mice lacking galectin-1 or galectin-3. Physiology & Behavior, v. 220, JUN 1 2020. (13/00279-5)

SARTIM, A. G.; MOREIRA, F. A.; JOCA, S. R. L.. INVOLVEMENT OF CB1 AND TRPV1 RECEPTORS LOCATED IN THE VENTRAL MEDIAL PREFRONTAL CORTEX IN THE MODULATION OF STRESS COPING BEHAVIOR. Neuroscience, v. 340, p. 126-134, JAN 6 2017. (12/17626-7, 13/00279-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SARTIM, Ariandra Guerini. Possible interaction between endocannabinoid, glutamatergic and nitrergic systems into the mvPFC in the modulation of emotional / behavioral response to stress. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.