Administration’s effects of anti-inflammatory in olfactory regeneration

• Grant number: 13/02631-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2013
• End date: April 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Isaias Glezer
• Grantee: Maria Rosa de Sá Santos
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

People with olfactory dysfunction had an important reduction of quality of life since they are excluded from the tasting process, perception of poisoned or rotten foods, and alert of the presence of volatile or toxic gases. Moreover, there is a risk of the development of depression and loss of interest in sexual activities. There are many causes for total or partial loss of smell (anosmia or hyposmia), and the infection and inflammatory process represent a big contribution to these types of loss. Acute sinusitis is a disease with a high incidence and most of the patients are prescribes antibiotics and steroidal anti-inflammatory, even when these don't actually show evidence of benefits. Very often are prescribed drugs for the improvement of symptoms of the diseases that causes anosmia, like sinusitis, even without knowing the effects of these drugs in the olfactory epithelium (OE) regeneration. Our ongoing studies suggest that the treatment with steroidal anti-inflammatory effect in the regeneration of OE. Thus, is justified a study about the effect of the use of these classes of drugs in the recovery of the OE, including conventional and non-conventional anti-inflammatory that has potential use for the treatment of inflammatory disease that causes anosmia. The result of this study can help in the characterization of collateral damages of the use of these drugs. Thereby, this project aims to survey the role of action of these anti-inflammatory drugs in OE regeneration through in vivo and in vitro experiments. (AU)