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Cardiorespiratory and sedatives effects of the dexmedetomidine in combination with methadone, morphine, tramadol or butorphanol in sheep.

Grant number: 12/23664-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2013
Effective date (End): May 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Ewaldo de Mattos Junior
Grantee:Luisa Pucci Bueno Borges
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil


With the objetive to verify the cardiorespiratory and sedative effects of dexmedetomidine in combination with methadone, morphine, butorphanol or tramadol in sheep, will be used 6 animals, males, Santa Ines, clinically healthy. They will be randomly divided into five groups of six animals in blinded crossover study, with minimum interval of 7 days between treatments. The groups are designated as D (dexmedetomidine 5 microg/kg), DM (dexmedetomidine 5 microg/kg + 0.5 mg/kg methadone), DMO (dexmedetomidine 5 g / kg + 0.5 mg / kg morphine), DT (dexmedetomidine 5 microg/kg + 5 mg/kg tramadol) and DB (dexmedetomidine 5 microg/kg + 0.1 mg/kg butorphanol), applied in combination in the same syringe i.v. Will be evaluated parameters of heart and respiratory rate, systolic, mean and diastolic blood pressure, rectal temperature, hydrogen potential in arterial blood (pHa), partial pressure of oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2), arterial oxygen saturation (SaO2), bicarbonate (HCO3), base deficit (DEB) and sedation. Data will be collected in the moments M0 to M120, with M0: basal, M15: 15 minutes after administration of the drugs and remainder moments corresponding to an interval of 15 minutes, a total of two hours of assessment. The results will be tested using the Shapiro-Wilk normality test, when the data present normal distribution will be employed analysis of variance (ANOVA) with repeated measures and Bonferroni's complementary analysis and variables with anormal distribution are compared with the Wilcoxon test. The significance level is 5%.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BORGES, LUISA P. B.; NISHIMURA, LILIAN T.; CARVALHO, LEONARDO L.; CEREJO, SOFIA A.; AUCKBURALLY, ADAM; MATTOS-JUNIOR, EWALDO. Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol, methadone, morphine or tramadol in conscious sheep. VETERINARY ANAESTHESIA AND ANALGESIA, v. 43, n. 5, p. 549-560, SEP 2016. Web of Science Citations: 2.

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