Study of DNM-1 c.767G>T mutation responsible for exercise-induced collapse in Labrador Retriever

• Grant number: 13/03076-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2013
• End date: May 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Alexandre Secorun Borges
• Grantee: Roberta Martins Basso
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The exercise-induced collapse (EIC) is considered a syndrome that mainly affects Labrador Retriever breed dogs. The disease is characterized by muscle weakness and collapse after intense exercise. Recovery usually occurs after exercise but some animals may die. The clinical signs occurs because the mutation c.767G> T in gene DNM-1 (dynamin 1, GenBankTM EU682271). Dogs homozygous for the mutation exhibit early signs of the disease with less than four years old when subjected to intense exercise, regardless of sex or coat color. The objective is to evaluate the occurrence of mutation c.767G> T in the gene DNM-1 in Labrador Retriever breed dogs using gene sequencing after amplification of DNA obtained from blood samples or buccal swab for PCR. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROBERTA M. BASSO; JOSÉ P. OLIVEIRA-FILHO; MARIANA I.P. PALUMBO; LUIZA S. ZAKIA; JOÃO P. ARAÚJO JR; ALEXANDRE S. BORGES. Ocorrência do SNP c.767G>T no gene DNM1responsável pelo colapso induzido pelo exercício em cães da raça Labrador Retriever no Estado de São Paulo. Pesquisa Veterinária Brasileira, v. 35, n. 5, p. 486-490, 2015-05-00. (13/03076-8)