Electrocardiogram strain pattern as a marker of carotid intima-media thickness in patients with aortic stenosis

• Grant number: 13/04845-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2013
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Meliza Goi Roscani
• Grantee: Gustavo Nicolodi Augusto
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Chronic aortic valve stenosis disease is quite prevalent in the world and the degenerative form has become the most common etiology in Brazil and an important cause of surgery for correction of valvular disease, morbidity, and death. Recent data point that in 30% of cases, degenerative aortic valve stenosis is associated with coronary artery disease. Atherosclerosis also performs an important role in the progression of aortic valve stenosis. Nevertheless, there are few studies that associate peripheral atherosclerosis and aortic valve stenosis. The electrocardiogram strain pattern of patients with aortic valve stenosis is associated with a worse prognosis and may indicate subendocardial ischemia. The aim of this study is to identify if the electrocardiogram strain pattern is a marker of peripheral ateroscleorese. The proposal of this study is to conduct a prospective study including consecutive patients referred from outpatient cardiology with aortic valve stenosis. Patients will be submitted to clinical evaluation, transthoracic echocardiography, and carotid ultrasonography. At this moment, we will investigate if the "strain" pattern is associated with carotid intima-media thickness in patients with aortic stenosis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSCANI, MELIZA GOI; AUGUSTO, GUSTAVO N.; VALADAO, TAINA F. C.; ARAUJO JUNIOR, JONAS A.; DUARTE, JULIANA C.; GOBBI, JULIANA I. F.; SILVEIRA, LICIANA V. A.; CONEGLIAN, REGINA C.; ROSSI, DANIELE A.; ZANATI, SILMEIA G.; et al. Strain Pattern on Electrocardiogram Is Associated with Increased Carotid Intima-Media Thickness in Patients with Aortic Valve Stenosis. ANNALS OF VASCULAR SURGERY, v. 35, p. 197-202, AUG 2016. (13/04845-5)