| Grant number: | 12/22836-0 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | July 01, 2013 |
| End date: | September 30, 2014 |
| Field of knowledge: | Biological Sciences - Pharmacology - Ethnopharmacology |
| Principal Investigator: | Regildo Márcio Gonçalves da Silva |
| Grantee: | Kamille Daleck Spera |
| Host Institution: | Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil |
Abstract The oxidative effect caused by free radicals derived from O2 metabolism occurs naturally in the human body. The oxidative stress, the increase of this condition, is correlated with the disease's appearance and can be intensified by the exposure of extern factors, like solar radiation, thus causing significant cellular damage and also may cause faster aging of cells. Researches with plant extracts have shown that they may have compounds with pharmacological interesting to healing and/or preventing cellular damages caused by oxidative stress. Those may cause a photoprotective and antiglicant activity. Among the plant species, the Annonaceae family has representatives that contain bioactive compounds with different pharmacological activities, making them important to the study of antioxidative capacity and its relation with photoprotective and antiglicant potential. Based on this, this project is designed to measure the oxidative, photoprotective and antiglicant potential in in vitro assays, and also to quantify the total phenols, flavonoids and condensed tannins in the samples. Another target is also to characterize by phytochemistry the extracts with higher antioxidant activity. | |
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