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EFFECT OF LOW-LEVEL LASER THERAPY AND GROWTH FACTORS ON GINGIVAL FIBROBLASTS ACTIVITY OF YOUNG AND AGED PATIENTS

Grant number: 12/25070-9
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:Carlos Alberto de Souza Costa
Grantee:Taisa Nogueira Pansani
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Tissue repair is related to several local events, such as cell proliferation and matrix protein synthesis, like collagen, elastin and reticular fibrils, which are directly associated to cell metabolism. Aging causes decrease of these cell functions, which can lead to the delay of wound repair. Gingival fibroblasts show greater repair capacity when compared to skin fibroblasts, but no studies have presented the influence of age on oral mucosa repair capacity as already shown for skin. Recent studies demonstrated that low-level laser therapy (LLLT) promotes biostimulation of different cell types and growth factors application, such as epithelial growth factors (EGF) accelerate repair process by increasing cell proliferation and migration capacity. Therefore, the present study aims to investigate cell metabolism, proliferation and migration capacity, which are cell functions related to repair capacity, of gingival fibroblasts of young and aged patients submitted or not to LLLT and treatment with growth factors.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PANSANI, TAISA NOGUEIRA; BASSO, FERNANDA GONCALVES; SILVEIRA TURRIONI, ANA PAULA; SOARES, DIANA GABRIELA; HEBLING, JOSIMERI; DE SOUZA COSTA, CARLOS ALBERTO. Effects of low-level laser therapy and epidermal growth factor on the activities of gingival fibroblasts obtained from young or elderly individuals. Lasers in Medical Science, v. 32, n. 1, p. 45-52, . (13/05879-0, 12/25070-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PANSANI, Taisa Nogueira. Resposta de fibroblastos da gengiva de pacientes jovens e idosos e efeito da laserterapia de baixa potência e de fator de crescimento sobre estas células. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.