Tissue repair is related to several local events, such as cell proliferation and matrix protein synthesis, like collagen, elastin and reticular fibrils, which are directly associated to cell metabolism. Aging causes decrease of these cell functions, which can lead to the delay of wound repair. Gingival fibroblasts show greater repair capacity when compared to skin fibroblasts, but no studies have presented the influence of age on oral mucosa repair capacity as already shown for skin. Recent studies demonstrated that low-level laser therapy (LLLT) promotes biostimulation of different cell types and growth factors application, such as epithelial growth factors (EGF) accelerate repair process by increasing cell proliferation and migration capacity. Therefore, the present study aims to investigate cell metabolism, proliferation and migration capacity, which are cell functions related to repair capacity, of gingival fibroblasts of young and aged patients submitted or not to LLLT and treatment with growth factors.
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