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Biomechanical effect of use of orthoses in gait in patients with Duchenne muscular dystrophy

Grant number: 13/03835-6
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2013
Effective date (End): June 30, 2014
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Ana Cláudia Mattiello-Sverzut
Grantee:Mariana Angélica de Souza
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Duchenne muscular dystrophy (DMD) is a disease determined by absence of dystrophin protein. The disease progression cause loss of muscular strenght, changes in range of motion and body composition. These changes lead to loss of ambulation, sedentary lifestyle and obesity. The bioelectrical impedance and 10 meters walk test (T10) are used to follow patients with DMD regarding body composition and gait analyze, respectively. In a previous study realized in this laboratory, the T10 detected temporal changes that influenced the loss of gait. The orthoses is an therapeutic strategy used to prolong ambulation. Thus, the aims this study are to evaluate the biomechanical effect of orthoses in gait and, follow disease progression through the acquisition of quantitative functional data during the study period. Male children with DMD will be followed clinically for a maximum period of 6 months in CER - HCFMRP-USP. The patients will be evaluated considering: muscular strength by Hand-Held dynamometer (Lafayette Instrument, Lafayette, UK), goniometry (passive range of motion) of the lower limbs, T10, body composition analysis by bioelectrical impedance and computerized gait analysis. To assess the results will be used descriptive analysis and regression models of mixed effects. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, MARIANA ANGELICA; CEZARANI, ANANDA; DA SILVA LIZZI, ELISANGELA APARECIDA; DE QUEIROZ DAVOLI, GABRIELA BARROSO; MATTIELLO, STELA MARCIA; JONES, RICHARD; MATTIELLO-SVERZUT, ANA CLAUDIA. The use of the gait profile score and gait variable score in individuals with Duchenne Muscular Dystrophy. JOURNAL OF BIOMECHANICS, v. 98, JAN 2 2020. Web of Science Citations: 0.
DE SOUZA, MARIANA ANGELICA; LEONARDI FIGUEIREDO, MARISA MAIA; DE JESUS ALVES DE BAPTISTA, CYNTIA ROGEAN; ALDAVES, ROBSON DEVANIR; MATTIELLO-SVERZUT, ANA CLAUDIA. Beneficial effects of ankle-foot orthosis daytime use on the gait of Duchenne muscular dystrophy patients. CLINICAL BIOMECHANICS, v. 35, p. 102-110, JUN 2016. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Mariana Angélica de. Effect of use of ankle-foot orthosis on the gait biomechanics of patients with Duchenne muscular dystrophy. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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