Human health risk quantification for multiple exposure routes to chemical pollutants and carcinogenic potential for adjacent communities of the Pardo river, Brazil

• Grant number: 13/03858-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2013
• End date: October 31, 2016
• Field of knowledge: Health Sciences - Nursing - Public Health Nursing
• Principal Investigator: Susana Segura Muñoz
• Grantee: Carolina Sampaio Machado
• Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 15/15421-7 - Fish consumption and pollution by metals: Human health risk evaluation, BE.EP.DR

Abstract

Natural and artificial chemical compounds are human incorporated by several routes, like ingestion, inhalation and dermal contact. Over the past decades, considerable efforts and progress have been made in the methodologies development to protect individuals against associated risks with toxic chemicals exposure. This project aims at risk quantifying to human health by multiple exposure routes to pesticides and metals in water river, sediment and fish species of interest for human consumption in the Pardo river, Brazil. Four sampling campaigns will be conducted at 12 points along the Pardo river, Brazil. The metals choice followed criterion of toxicity to organisms, namely Cd, Cr, Cu, Hg, Mn, Ni, Pb and Zn, and metals in river water will be sampled by passive method (DGT). The same metals will be quantified in the sediment and fish. Pesticides prioritized in this study are the most used in the region cultures (sugar cane, oranges and coffee), namely DDT and its metabolites, HCHs, Heptachlor, Heptachlor epoxide, aldrin, dieldrin, endrin and endosulfan, atrazine, ametrina, simazine, metribuzin, diuron, acetochlor, tebuthiuron, hexazinone, deethylatrazine. The human health risk quantification will be evaluated by Monte Carlo simulation and the laboratory analyzes results will be compared with national and international legislations. Studies about human health risk quantification for multiple exposure routes to chemical pollutants are still scarce in Brazil and generate important results in the Public Health context.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACHADO, CAROLINA S.; ALVES, RENATO I. S.; FREGONESI, BRISA M.; TONANI, KARINA A. A.; MARTINIS, BRUNO S.; SIERRA, JORDI; NADAL, MARTI; DOMINGO, JOSE L.; SEGURA-MUNOZ, SUSANA; KANAKOUDIS, V; et al. Chemical contamination of water and sediments in the Pardo River, Sdo Paulo, Brazil. X INTERNATIONAL CONFERENCE ON STRUCTURAL DYNAMICS (EURODYN 2017), v. 162, p. 8-pg., 2016-01-01. (13/03858-6, 15/15421-7)

MACHADO, CAROLINA S.; FREGONESI, BRISA M.; ALVES, RENATO I. S.; TONANI, KARINA A. A.; SIERRA, JORDI; MARTINIS, BRUNO S.; CELERE, BEATRIZ S.; MARI, MONTSE; SCHUHMACHER, MARTA; NADAL, MARTI; et al. Health risks of environmental exposure to metals and herbicides in the Pardo River, Brazil. Environmental Science and Pollution Research, v. 24, n. 25, p. 20160-20172, SEP 2017. (13/07238-2, 13/03858-6, 15/15421-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MACHADO, Carolina Sampaio. Human health risk quantification from exposure to chemical pollutants and carcinogenic potential to communities adjacent to the Pardo River, Brazil. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto (PCARP/BC) Ribeirão Preto.