Manganeseporphyrin immobilized onto Fe3O4@nSiO2@MCM-41 magnetic composite: biomimetic catalyst applied on hydrocarbons and drug oxidation.

• Grant number: 13/08439-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2013
• End date: February 28, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Yassuko Iamamoto
• Grantee: Fabrício Bortulucci Zanardi
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

In this project we intend to synthesize, characterize and study biomimetic catalysts consisting of metalloporphyrins (MeP) immobilized on silica matrix. We will functionalize two materials, that consisting of magnetite (Fe3O4) nanoparticles dispersed in to MCM-41 mesoporous silica in order to obtain the heterogeneous catalysts with expanded pores (Fe3O4@nSiO2@MCM-41(E)-MnP) and non-expanded pores (Fe3O4@nSiO2@MCM-41-MnP). We will characterize both catalysts by infrared absorption spectroscopy and ultraviolet-visible diffuse reflectance spectroscopy, X-ray diffraction, N2 adsorption-desorption isotherms and electron microscopy (scanning and transmission). We will assess the catalytic activities of the materials in the oxidation of the hydrocarbons (Z)-cyclooctene and cyclohexane, using PhIO or m-CPBA as oxidants. We wish to understand the oxidative processes and relate then to structural and morphological properties such as the nature of the microenvironment created in the active site of MnP and the accessibility of substrates to this site. Futhermore to evaluate the behavior of the biomimetic catalysts Fe3O4@nSiO2@MCM-41(E) and Fe3O4@nSiO2@MCM-41 we will conduct metabolism studies of the antidepressant mirtazapine (MTZ) and analyze the metabolites by High Performance Liquid Chromatography (HPLC).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOSA, ISALTINO A.; DE SOUSA FILHO, PAULO C.; DA SILVA, DOUGLAS L.; ZANARDI, FABRICIO B.; ZANATTA, LUCAS D.; DE OLIVEIRA, ADILSON J. A.; SERRA, OSVALDO A.; IAMAMOTO, YASSUKO. Metalloporphyrins immobilized in Fe3O4@SiO2 mesoporous submicrospheres: Reusable biomimetic catalysts for hydrocarbon oxidation. Journal of Colloid and Interface Science, v. 469, p. 296-309, MAY 1 2016. (13/01669-1, 13/08439-1, 14/22930-2)

ZANARDI, FABRICIO B.; BARBOSA, ISALTINO A.; DE SOUSA FILHO, PAULO C.; ZANATTA, LUCAS D.; DA SILVA, DOUGLAS L.; SERRA, OSVALDO A.; IAMAMOTO, YASSUKO. Manganese porphyrin functionalized on Fe3O4@nSiO(2)@MCM-41 magnetic composite: Structural characterization and catalytic activity as cytochrome P450 model. Microporous and Mesoporous Materials, v. 219, p. 161-171, JAN 1 2016. (13/01669-1, 13/08439-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ZANARDI, Fabrício Bortulucci. Manganeseporphyrin immobilized onto Fe3O4@nSiO2@MCM-41 magnetic composite: biomimetic catalyst applied on hydrocarbons and drug oxidation. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.