Naproxen encapsulated in nanostructured lipid carriers for parenteral administration: preparation, characterization and pharmacological evaluation.

• Grant number: 13/10766-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2013
• End date: August 31, 2016
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Eneida de Paula
• Grantee: Viviane Aparecida Guilherme Damasio
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Compounds anti-inflammatory drugs (NSAIDs) are widely used to combat inflammation, but often cause side effects which hinder the continued treatment. The use of carrier systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), aims to improve biopharmaceutical and pharmacological properties of the compounds in them interspersed. In this context, naproxen, an anti-inflammatory highly used in clinical medicine, presents a strong candidate for this type of entrainment, since it has low solubility and is therefore not used by parenteral routes which diminishes its potential application hospital. The tests used in this study aimed at the development of a formulation for parenteral administration of naproxen using the CLN. Evaluations will be done on the effectiveness of the formulation by molecular methods and in vivo tests and stability of the formulations will also be examined.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUILHERME, VIVIANE A.; RIBEIRO, LIGIA N. M.; ALCANTARA, ANA C. S.; CASTRO, SIMONE R.; RODRIGUES DA SILVA, GUSTAVO H.; DA SILVA, CAMILA GONCALVES; BREITKREITZ, MARCIA C.; CLEMENTE-NAPIMOGA, JULIANA; MACEDO, CRISTINA G.; ABDALLA, HENRIQUE B.; et al. Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration. SCIENTIFIC REPORTS, v. 9, AUG 1 2019. (13/10766-0, 14/14457-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DAMASIO, Viviane Aparecida Guilherme. Naproxen encapsulated in nanostructureted lipid carries for parenteral administration: from preparation to pharmacological tests. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.