Analyses of structural changes in primary craniocervical dystonia through the software Freesurfer

• Grant number: 13/13270-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2013
• End date: August 31, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Fernando Cendes
• Grantee: Larissa Núbia Nunes Vilany
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Craniocervical dystonia (CCD) is a neurological disorder that courses with involuntary muscle contractions, generating abnormal movements and postures. CCD includes the focal presentations of dystonia: blepharospasm, cervical, oromandibular, lingual and laryngeal dystonia. Its physiopathology has not been fully understood yet and neuroimage studies, using the voxel based morphometry, have described different structural changes on patients with the disease. These results, however, haven't been congruent among themselves. In such context, the automatized method of Freesurfer arises as an alternative, which has been showing a good validation by neurological studies. Therefore, this study aims to notice encephalic structural changes in CCD, through the use of the Freesurfer software.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VILANY, LARISSA; DE REZENDE, THIAGO J. R.; PIOVESANA, LUIZA G.; CAMPOS, LIDIANE S.; DE AZEVEDO, PAULA C.; TORRES, FABIO R.; FRANCA, JR., MARCONDES C.; AMATO-FILHO, AUGUSTO C.; LOPES-CENDES, ISCIA; CENDES, FERNANDO; et al. Exploratory structural assessment in craniocervical dystonia: Global and differential analyses. PLoS One, v. 12, n. 8, AUG 22 2017. (13/07559-3, 13/13270-6, 10/11085-9)