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Assessment of changes in senile plaques and cholinergic markers in the brain of mice subjected to a model of neurodegeneration after training attention

Grant number: 13/06935-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2013
Effective date (End): August 31, 2014
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal researcher:Tânia Araújo Viel
Grantee:Gabriela Cabett Cipolli
Home Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Throughout the aging process functions decline naturally, but in most cases individuals adapt to these changes and maintain their quality of life and daily activities. However, in the presence of neurodegenerative diseases common to aging, such as Alzheimer's disease (AD), the quality of life may be compromised. Memory is one of the cognitive functions that are impaired in the case of AD. Memory formation does not depend on isolated nerve structures, but rather on the intense connection between structures such as cortex, hippocampus and amygdala. Modulation of memory occurs through the action of neurotransmitters. Here, we stands out the cholinergic system, which plays an important role in formation of LTP (long-term potentiation), which is closed related to long-term memory. Additionally, it has been reported that the nicotinic cholinergic receptor ±7 has active participation in the degradation of amyloid-² peptide. In this project, the amount and density of senile plaques and ±7 nicotinic receptors will be evaluated in the frontal cortex, hippocampus and amygdala of mice submitted to an experimental model of neurodegeneration and a weekly attention training, which promoted memory improvement, as described earlier (Viel et al., Curr.Alzh. Res, 2012). In this model, the animals infused with ±7 nicotinic receptor antagonist, metillycaconitine, showed no improvement in memory. In this way, we intend to evaluate, in more detail, the effects of attention training to the cholinergic system and memory formation, in order to investigate which area of the brain (cortex, hippocampus or amygdala) was inhibited by the chronic infusion of metillycaconitine (or if all of them were inhibited), leading to the lack of memory retrieval. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TELLES-LONGUI, MILENA; MOURELLE, DANILO; SCHOWE, NATALIA MENDES; CIPOLLI, GABRIELA CABETT; MALERBA, HELENA NASCIMENTO; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. alpha 7 nicotinic ACh receptors are necessary for memory recovery and neuroprotection promoted by attention training in amyloid-beta-infused mice. British Journal of Pharmacology, v. 176, n. 17 JULY 2019. Web of Science Citations: 0.
BALTHAZAR, JANAINA; SCHOWE, NATALIA MENDES; CIPOLLI, GABRIELA CABETT; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory. FRONTIERS IN AGING NEUROSCIENCE, v. 10, SEP 26 2018. Web of Science Citations: 1.

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