Rate of the process repair after incison in tongue with a conventional scalpel and Harmonic® scalpel: clinical study in drug-induced rats during Warfarin anticoagulation

• Grant number: 13/11579-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2013
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Walter Domingos Niccoli Filho
• Grantee: Hárina Prates Vilas Bôas
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The use of drugs such as oral anticoagulants (OAC) has become a common practice due to advances in surgical techniques and therapies in the treatment of cardiovascular diseases. The oral surgery in general present risks such as infection, swelling, pain and bleeding especially when using OAC. The harmonic scalpel converts electrical energy into mechanical vibration, resulting in simultaneous cutting and coagulation. Our objectives will be to examine the quality of repair of lateral border of the tongue of rats subjected to harmonic scalpel incision and conventional scalpel. Sixty adult rats experimentally anticoagulated with warfarin in oral ingestion. The evaluation of international normalization ratio (INR) and prothrombin time be performed after one week of administration of anticoagulants. The animals are divided into four groups: group I - incised wound by Harmonic Scalpel® in animals induced oral anticoagulation group II - incised wound by conventional scalpel in animals induced oral anticoagulation, group III - incised wound by Harmonic Scalpel ® in animals without induction of oral anticoagulation and group IV - incised wound by conventional scalpel in animals without induction of oral anticoagulation. Through clinical analysis of lingual tissue compared between techniques with conventional scalpel and harmonic scalpel in the course of the use of oral anticoagulants. Expected Results: Reduced bleeding and surgical time in the groups treated with harmonic scalpel, reduction of possible postoperative complications in the groups treated with harmonic scalpel, faster tissue repair in the groups treated with the technique of harmonic scalpel.