Regulating the expression of heat shock proteins by hepatitis C virus

• Grant number: 13/17253-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2013
• End date: August 31, 2017
• Field of knowledge: Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
• Principal Investigator: Paula Rahal
• Grantee: Ana Cláudia Silva Braga
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

Hepatitis C is a disease caused by hepatitis C virus (HCV), and it is estimated that about 170 million people are infected worldwide. HCV interacts with multiple cellular proteins in order to promote viral replication. Studies have shown that, besides exhibit an altered expression profile in the presence of the virus, certain heat shock proteins (Hsp) they also may interact with HCV proteins and the increase or decrease in the expression of Hsp may be an alternative effective in reducing viral replication. This makes the heat shock proteins an important target for anti-HCV studies. Thus the present study aims to evaluate in vitro the expression of heat shock proteins in the presence and absence of HCV and retake the Hsp expression of Hsp with abnormal profile (up and down expression) in order to inhibit viral replication. The Hsp with best result um viral inhibition will be evaluated for possible physical interactions with key viral proteins involved in HCV replication.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SILVA BRAGA, ANA CLAUDIA; CARNEIRO, BRUNO MOREIRA; BATISTA, MARIANA NOGUEIRA; AKINAGA, MONICA MAYUMI; BITTAR, CINTIA; RAHAL, PAULA. Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity. PLoS One, v. 12, n. 11, NOV 28 2017. (13/17253-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BRAGA, Ana Cláudia Silva. Regulation of heat shock proteins by hepatitis C virus. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.