Paroxetine effect in ventricular systolic function of rats with volume overload induced by experimental acute aortic regurgitation

• Grant number: 13/14872-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2013
• End date: November 30, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Meliza Goi Roscani
• Grantee: Priscila Garcia Viveiros
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Heart failure is a syndrome of great public health importance and the most frequent cause of hospitalization for cardiovascular disease. Depression is a serious and highly prevalent in patients with heart failure. The deficiency of serotonin may cause or exacerbate cardiac abnormalities in patients with heart failure, leading to progressive loss of ventricular function and increased cardiovascular risk. The role of selective serotonin reuptake inhibitors in the ventricular function in patients with heart failure is not well known. Purpose: to evaluate the effect of paroxetin in ventricle systolic function in rats with acute volume overload induced by experimental aortic regurgitation. Methods: Four experimental groups (n=10). Initially, aortic regurgitation or sham operation will be performed. Four weeks later, paroxetin at a dose of 15mg/kg/day or isotonic saline vehicle will be administrated subcutaneous for 4 weeks. Control Group: sham operation + isotonic saline vehicle. AR group: aortic regurgitation surgery + isotonic saline vehicle. PARO group: sham operation + paroxetin injection. AR+PARO group: aortic regurgitation surgery + paroxetin injection. Echocardiogram will be performed to analyze morphological and functional cardiac variables with 4 and 8 weeks. Statistical analysis will be performed to assess differences between groups. Expected results: we hope that paroxetine plays a benefical role in left ventricle systolic function of rats with experimental heart failure.