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Metabolite connectivity using 1H-MRS

Grant number: 13/19340-6
Support Opportunities:Scholarships abroad - Research
Start date: February 23, 2014
End date: February 22, 2015
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal Investigator:Carlos Ernesto Garrido Salmon
Grantee:Carlos Ernesto Garrido Salmon
Host Investigator: Peter Gordon Morris
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Institution abroad: University of Nottingham, University Park, England  

Abstract

Nowadays, the connectivity between several brain regions is widely recognized and studied. This brain connectivity could be structural or functional depend on the techniques involved and plays crucial roles in determining the functional properties of neuronal systems. The frequency range of these connectivities is around 0.01-0.08 Hz. Magnetic Resonance Spectroscopy (MRS) is a powerful tool for biochemical in vivo studies of several metabolites. In vivo metabolite variations have been detected in a specific brain region with MRS during a task. Positron Emission Tomography studies with glucose have suggested temporal metabolite correlations between remote cerebral areas, but this connectivity is related with energetic metabolism of the glycolysis pathway. To acquire spectroscopy data from several areas is time demanding. The aim of this project is to detect and quantify any metabolite connectivity in resting state and task related with primary areas (visual or motor). To increase the temporal resolution will be used the signal from several coils independently. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES, CAROLINA C.; LANZ, BERNARD; CHEN, CHEN; MORRIS, PETER G.; SALMON, CARLOS G.. Investigating the regional effect of the chemical shift displacement artefact on the J-modulated lactate signal at ultra high-field. NMR in Biomedicine, v. 34, n. 2, . (13/19340-6)