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Temporomandibular joint osteoarthritis. three-dimensional quantitative assessment of condylar remodeling after maxillomandibular counterclockwise rotation and mandibular advancement surgery

Grant number: 13/22417-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 13, 2014
Effective date (End): March 12, 2015
Field of knowledge:Health Sciences - Dentistry - Orthodontics
Principal researcher:João Roberto Gonçalves
Grantee:Liliane de Carvalho Rosas Gomes
Supervisor abroad: Lucia Helena Soares Cevidanes
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: University of Michigan, United States  
Associated to the scholarship:13/09986-6 - Temporomandibular joint osteoarthritis. Three-dimensional quantitative assessment of condylar remodeling after maxillomandibular counterclockwise rotation and mandibular advancement surgery, BP.DR


The purpose of this project is to study temporomandibular joint (TMJ) osteoarthritis and its relationship with potential predisposing factors by new computational techniques developed to optimize the use of three-dimensional (3D) images. It will be evaluated Cone Beam Computed Tomography (CBCT) scans of 100 patients (50 women and 50 men) who underwent counterclockwise maxillomandibular advancement surgery, obtained at the following intervals: T1, presurgery; T2, immediately after surgery; and T3, at least 11 months after surgery. The sample will be divided into 2 groups: Group 1, patients with articular disc displacement (DD) who underwent articular disc repositioning surgery; Group 2, patients without DD who did not undergo TMJ surgical intervention. Firstly, it will be tested the validity of a new method for 3D assessment of the mandibular condyles, which proposes voxel-based regional registration and shape correspondence measurements. The proposed method will be applied for assessing condylar changes after mandibular advancement surgery with counterclockwise rotation of the maxillomandibular complex, with or without TMJ surgical intervention. Statistical analysis will be conducted to test the reproducibility of the method; to quantitatively evaluate condylar remodeling in each group; and to identify differences between the groups. The validation and application of the proposed methodology may be useful for diagnosis, risk factors identification, prognosis prediction and surgical outcomes analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, LILIANE ROSAS; SOARES CEVIDANES, LUCIA HELENA; GOMES, MARCELO REGIS; DE OLIVEIRA RUELLAS, ANTONIO CARLOS; OBELENIS RYAN, DANIEL PATRICK; PANIAGUA, BEATRIZ; WOLFORD, LARRY MILLER; GONCALVES, JOAO ROBERTO. Three-dimensional quantitative assessment of surgical stability and condylar displacement changes after counterclockwise maxillomandibular advancement surgery: Effect of simultaneous articular disc repositioning. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, v. 154, n. 2, p. 221-233, . (13/22417-0)
GOMES, LILIANE ROSAS; GOMES, MARCELO REGIS; GONCALVES, JOAO ROBERTO; RUELLAS, ANTONIO CARLOS O.; WOLFORD, LARRY M.; PANIAGUA, BEATRIZ; BENAVIDES, ERIKA; CEVIDANES, LUCIA HELENA SOARES. Cone beam computed tomography-based models versus multislice spiral computed tomography-based models for assessing condylar morphology. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 121, n. 1, p. 96-105, . (13/22417-0)
GOMES, LILIANE R.; GOMES, MARCELO; JUNG, BRYAN; PANIAGUA, BEATRIZ; RUELLAS, ANTONIO C.; GONCALVES, JOAO ROBERTO; STYNER, MARTIN A.; WOLFORD, LARRY; CEVIDANES, LUCIA. Diagnostic index of three-dimensional osteoarthritic changes in temporomandibular joint condylar morphology. JOURNAL OF MEDICAL IMAGING, v. 2, n. 3, . (13/22417-0)

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