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Phototherapy and physical exercise: potential effects on the role of irisin and factores anorexigen and orexigen

Grant number: 13/19046-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2013
Effective date (End): November 30, 2015
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Vanderlei Salvador Bagnato
Grantee:Marcela Sene Fiorese
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Introduction: With the increase in obesity, the main form of treatment is the regulation of energy balance, with decreased caloric intake and / or increased energy expenditure, so that a reduction of adipose tissue occurs. Thus, the interaction between muscle and adipose tissue has been recognized as an important factor in maintaining body mass, highlighting the Irisin. The irisina is processed from products of the BDNF 5 gene in the skeletal muscle, whose expression is stimulated by PGC1± and PPAR ³. In fact, the exercise and the phototherapy singly are able to induce the release of PGC1± by muscle, which promotes mitochondrial biogenesis, angiogenesis and changes in muscle fiber type. Moreover, the irisina has been studied for its role in mediating the transdifferentiation of the subcutaneo adipose tissue for the thermogenic brown adipose tissue. These changes cause a significant increase in energy expenditure, which is an important factor for the maintenance and or loss of body mass. Thus, experimental evidence shows that the use of laser therapy combined with exercise swimming was effective in controlling the lipid profile, reducing the mass of adipose tissue, suggesting increased metabolic activity and changes in lipid metabolism. However, we not found data in the literature about the neuroendocrine modulation of energy balance or just of the thermogenesis involving the use of laser therapy and exercise in the obese population.Objective: Evaluate the effect of the use of laser therapy on the circulating irisina levels and anorexigenic and orexigenic factors associate to the aerobic exercise and interdisciplinary therapy for weight loss.Methodology: The study population will consist of 128 women, with 20-40 years old, body mass index (BMI) e 30 and <40, obese primary, divided into four groups (n = 32): 1) aerobic; 2) aerobic + phototherapy; 3) aerobic + sham and, 4) phototherapy. Will be evaluated the body composition, clinical and nutritional and lifesty. The blood will be collected for analyses. The study protocol should last 20 weeks comprising for three weekly sessions of aerobic exercise and application of phototherapy (when applicable).

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; DAMASO, ANA RAIMUNDA; LANDI MASQUIO, DEBORAH CRISTINA; DUARTE, FERNANDA OLIVEIRA; SENE-FIORESE, MARCELA; AQUINO, JR., ANTONIO EDUARDO; SAVIOLI, FILIPPO ARAGAO; LOPES QUINTILIANO, PAMELA CRISTINA; PELISSARI KRAVCHYCHYN, ANA CLAUDIA; GUIMARAES, LILIANE ISABEL; TOCK, LIAN; OYAMA, LILA MISSAE; BOLDARINE, VALTER TADEU; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO. The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. Lasers in Medical Science, v. 33, n. 6, p. 1245-1254, AUG 2018. Web of Science Citations: 2.
DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; DE CARVALHO-FERREIRA, JOANA PEREIRA; NETTO, BARBARA DAL MOLIN; GROTTI CLEMENTE, ANA PAULA; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO TULIO; DAMASO, ANA RAIMUNDA. Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 3, p. 275-284, MAY-JUN 2018. Web of Science Citations: 4.
PELISSARI KRAVCHYCHYN, ANA CLAUDIA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CORGOSINHO, FLAVIA CAMPOS; LANDI MASQUIO, DEBORAH CRISTINA; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; MARTINS FERREIRA, YASMIN ALABY; SILVA, PATRICIA LEAO; GANEN, ALINE DE PIANO; OYAMA, LILA MISSAE; TOCK, LIAN; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA. The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents. ANNALS OF NUTRITION AND METABOLISM, v. 72, n. 4, p. 279-286, 2018. Web of Science Citations: 0.
RAQUEL MUNHOZ DA SILVEIRA CAMPOS; DEBORAH CRISTINA LANDI MASQUIO; FLÁVIA CAMPOS CORGOSINHO; JOANA PEREIRA DE CARVALHO-FERREIRA; BÁRBARA DAL MOLIN NETTO; ANA PAULA GROTTI CLEMENTE; LIAN TOCK; SERGIO TUFIK; MARCO TÚLIO DE MELLO; ANA RAIMUNDA DÂMASO. Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 3, p. -, Maio 2018.
DUARTE, FERNANDA OLIVEIRA; SENE-FIORESE, MARCELA; DE AQUINO JUNIOR, ANTONIO EDUARDO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; TOCK, LIAN; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA; DAMASO, ANA RAIMUNDA; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO. Can low-level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women? A placebo-controlled clinical trial. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 153, p. 103-110, DEC 2015. Web of Science Citations: 5.
SENE-FIORESE, MARCELA; DUARTE, FERNANDA OLIVEIRA; DE AQUINO JUNIOR, ANTONIO EDUARDO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; TOCK, LIAN; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA; DAMASO, ANA RAIMUNDA; PARIZOTTO, NIVALDO ANTONIO; BAGNATO, VANDERLEI SALVADOR. The Potential of Phototherapy to Reduce Body Fat, Insulin Resistance and ``Metabolic Inflexibility{''} Related to Obesity in Women Undergoing Weight Loss Treatment. Lasers in Surgery and Medicine, v. 47, n. 8, p. 634-642, OCT 2015. Web of Science Citations: 9.
DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; DAMASO, ANA RAIMUNDA; LANDI MASQUIO, DEBORAH CRISTINA; AQUINO, JR., ANTONIO EDUARDO; SENE-FIORESE, MARCELA; DUARTE, FERNANDA OLIVEIRA; TOCK, LIAN; PARIZOTTO, NIVALDO ANTONIO; BAGNATO, VANDERLEI SALVADOR. Low-level laser therapy (LLLT) associated with aerobic plus resistance training to improve inflammatory biomarkers in obese adults. Lasers in Medical Science, v. 30, n. 5, p. 1553-1563, JUL 2015. Web of Science Citations: 6.

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