Investigation of the effects of Rhodiola rosea and green tea (Camellia sinensis) extracts in animals transplanted with the U037 leukemia strain

• Grant number: 13/21539-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2013
• End date: February 29, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Sara Teresinha Olalla Saad
• Grantee: Rodrigo Naoto Shiraishi
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/51959-0 - Biology of neoplastic diseases of bone marrow, AP.TEM

Abstract

Although in recent decades the pharmaceutical industry has given attention to synthetic products, nowadays, the necessity of effective and with less adverse effects compounds have extended the research of alternative therapies, mainly of derivatives from plants. Previous studies from our group identify the Rhodiola rosea and Green tea extract with potential immunomodulatory drugs. These products can also reduce cellular proliferation and induce neoplastic cell death. The evidence of these species in modulating the molecular mechanism of cancer allows their clinical utilization. Then, we intend to study the cell signaling related to the action of these products in mice inoculated with leukemic cells, U937. Considering our experience and instrumentalization for pathophysiological investigation, we intend to study the cellular and molecular effects of these compounds. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SHIRAISHI, RODRIGO N.; BOMBEIRO, ANDRE L.; CASTRO, TAMARA C. L.; DELLA VIA, FERNANDA I.; SANTOS, IRENE; REGO, EDUARDO M.; SAAD, SARA T. O.; TORELLO, CRISTIANE O.. PML/RARa leukemia induced murine model for immunotherapy evaluation. TRANSPLANT IMMUNOLOGY, v. 81, p. 14-pg., 2023-08-26. (13/21539-5, 17/21801-2, 11/51959-0)