Phenotypic and molecular characterization of soil bacterial isolates with carbapenem resistance

• Grant number: 13/20933-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2014
• End date: December 31, 2014
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Eliana Guedes Stehling
• Grantee: Beatriz Baptistella Devechio
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The soil has a large microbial diversity and the main species found belong to the genera Bacillus, Clostridium, Arthrobacter, Pseudomonas, Rhizobium, Azotobacter and Nitrobacter. Among these species of bacteria, Pseudomonas stands out, which is considered an opportunistic pathogen, causing infections of great clinical relevance. These bacteria are becoming increasingly resistant to antibiotics in recent years, can be found in nature organisms which are resistant to antimicrobial therapy, or antibiotics are used in clinical medicine today. One of the mechanisms of acquired resistance to carbapenems to imipenem and meropenem is metallo-b-lactamase (MBL).This research project aims to study the profile and mechanisms of antimicrobial resistance to some ²-lactam class of carbapenems (imipenem and meropenem) in bacterial isolates obtained from different species and soil of the five Brazilian regions. (AU)