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Analysis of activator and regulatory molecules of CD4+ T cells and CD4+CD25+ t reg cells in mice with Systemic Lupus Erythematosus (SLE) pristane-induced

Grant number: 13/19292-1
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): February 01, 2014
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Claudia Goldenstein Schainberg
Grantee:Tatiana Vasconcelos Peixoto
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Systemic Lupus Erythematosus is an autoimmune disease that affects about 80,000 people in Brazil. It has a complex etiology involving environmental, genetic and hormonal factors. It is a multisystemic, characterized by loss of immunologic tolerance with self-production and expansion of autoreactive T cells and production of inflammatory mediators and autoantibodies. The cellular receptors CD69 and CD28 are essential for maintaining the activation and proliferation of self-reactive CD4 T cells. In contrast, the CTLA-4 is a negative regulator of CD4 T cells, inhibiting their activation and proliferation. The activity of self-reactive CD4 T cells is also controlled by suppressor/regulatory CD4+ CD25+ T cells (Treg). The expression of CD69 and CD28 on CD4+ CD25+ T cells is important for the maintenance of their suppressive activity and CTLA-4 regulates signal transduction and differentiation of these cells. Because the heterogeneity of the expression of lupus in the population, experimental studies that develop pathology similar to human syndromes are important. The administration of pristane in Balb/c mice induces inflammatory responses with production of autoantibodies, reproducing many factors serological, histopathological and clinical features of human lupus. The melanocyte stimulating hormone (MSH) has anti-inflammatory effect capable of inhibiting the activation and proliferation of CD4 T cells. Thus, the objective is to evaluate the expression of activating molecules CD69 and CD28 and the regulatory molecule CTLA-4 in CD4 T cells and CD4+ CD25+ Treg cells from peripheral blood of Balb/c mice with pristane-induced SLE, suggesting this murine model may generate new knowledge concerning immunological abnormalities found in SLE, contributing to the understanding etiopathogenic aspects of human lupus. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEIXOTO, TATIANA VASCONCELOS; CARRASCO, SOLANGE; CICCONE BOTTE, DOMINGOS ALEXANDRE; CATANOZI, SERGIO; PARRA, EDWIN ROGER; LIMA, THAIS MARTINS; UGRIUMOV, NATASHA; SORIANO, FRANCISCO GARCIA; VERISSIMO DE MELLO, SUZANA BEATRIZ; RODRIGUES, CAIO MANZANO; GOLDENSTEIN-SCHAINBERG, CLAUDIA. CD4(+)CD69(+) T cells and CD4(+)CD25(+)FoxP3(+) Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice. ADVANCES IN RHEUMATOLOGY, v. 59, JUL 24 2019. Web of Science Citations: 0.
TATIANA VASCONCELOS PEIXOTO; SOLANGE CARRASCO; DOMINGOS ALEXANDRE CICCONE BOTTE; SERGIO CATANOZI; EDWIN ROGER PARRA; THAÍS MARTINS LIMA; NATASHA UGRIUMOV; FRANCISCO GARCIA SORIANO; SUZANA BEATRIZ VERISSÍMO DE MELLO; CAIO MANZANO RODRIGUES; CLÁUDIA GOLDENSTEIN-SCHAINBERG. CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice. ADVANCES IN RHEUMATOLOGY, v. 59, p. -, 2019.

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