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Grant number: 13/25312-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2014
Effective date (End): February 28, 2015
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Roberto Carvalheiro
Grantee:Giovana Vargas
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Important changes regarding the cultural and economic characteristics have directed livestock producers to apply modern technologies in order to achieve the genetic progress and increase productivity in animal husbandry. Morphological traits, such as the animal's aplomb, are of great importance the body's sustainment and mobility. Culling process based on defects in the aplombs represents a relevant productive loss. Nowadays, molecular data of livestock species are gaining more attention by the animal breeding programs and producers, because of the implementation of genomic tools. These tools considers the information of a massive number of single nucleotide polymorphism (SNP) present along animal's genome to estimate genomic breeding values with higher accuracy than the traditional phenotype-pedigree evaluation and aid in the selection process (i.e. genomic selection). Another application of this molecular information is to evaluate the existence of significant association of molecular markers (i.e. SNPs) and phenotypes, also known as genome-wide association studies (GWAS). Thus, the objectives of this study are to estimate genetic parameters for aplomb traits in Nellore cattle, as well as conduct GWAS for this trait to identify possible genomic regions that are related to the trait' expression. Phenotypic data from 245 farms will be provided by the PAINT breeding program. The genetic parameters will be estimated using the animal model, by means of a threshold analysis. The GWAS analyses will be conducted by means of the "weighted single step GBLUP" method. The results obtained in this study could provide substantial information for the Nellore breeding program.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VARGAS, GIOVANA; NEVES, HAROLDO H. R.; CAMARGO, GREGORIO MIGUEL F.; CARDOSO, VANIA; MUNARI, DANISIO P.; CARVALHEIRO, ROBERTO. Genome-wide association study and functional analysis of feet and leg conformation traits in Nellore cattle. JOURNAL OF ANIMAL SCIENCE, v. 96, n. 5, p. 1617-1627, . (13/25312-5)
VARGAS, G.; NEVES, H. H. R.; CARDOSO, V.; MUNARI, D. P.; CARVALHEIRO, R.. Genetic analysis of feet and leg conformation traits in Nelore cattle. JOURNAL OF ANIMAL SCIENCE, v. 95, n. 6, p. 2379-2384, . (13/25312-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VARGAS, Giovana. Genetic analysis of feet and legs in Nelore cattle. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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