Immunohistochemical study of estrogen and progesterone receptors in the vaginal epithelium using Glycine max (L.) Merr isoflavones vaginally on postmenopausal women

• Grant number: 13/21018-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2014
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Sonia Maria Rolim Rosa Lima
• Grantee: Larissa Matsuda de Sales Vieira
• Host Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil

Abstract

The climacteric is the period following the childbearing age and prior to old age and it is characterized by a gradual reduction in ovarian function, and although it is physiological, it manifests itself differently for every woman. The serum reduction in estrogen causes physiological changes that may affect the expression of estrogen and progesterone receptors. The use of phytoestrogens such as isoflavones derived from Glycine max (L.) Merr as topical vaginal creams may cause a significant change in the receptors in the vaginal epithelium.