Analysis of fresh cells of the periodontal ligament and the biomodificador effect aiming the regeneration of the periodontal tissue

• Grant number: 13/25990-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2014
• End date: February 29, 2016
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Mario Taba Junior
• Grantee: Carla de Oliveira Pires da Silva
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Periodontitis is a multifactorial chronic inflammatory disease highly prevalent in the population, which affects the supporting tissues of the teeth generating sequels difficult to solve even with the most modern regenerative techniques. Cell therapy seems to be a promising alternative and undifferentiated cells of the periodontal ligament (PDLSC) has shown great therapeutic potential. However, PDLSC require appropriate stimuli biomodificadores for the differentiation to occur. The Enamel Matrix Derivative (EMD) is a type of biomodificador that promotes periodontal regeneration through formation of new cementum. Despite being used clinically, its association with fresh periodontal ligament cells has not been explored. The objective of this study is to evaluate the regenerative potential of cells removed from the periodontal ligament and identify the feasibility of association with the EMD through the analysis of gene expression and protein. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Carla de Oliveira Pires da. Evaluation of the tissue viability of fresh periodontal ligament under the influence of enamel matrix proteins and their angiogenic potential. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (PCARP/BC) Ribeirão Preto.