| Grant number: | 14/00759-0 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | April 01, 2014 |
| End date: | January 31, 2018 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery |
| Principal Investigator: | Maria Claudia Araripe Sucupira |
| Grantee: | Aline Alberti Morgado |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Abomasal ulcers cause great, difficult to estimate, economic losses. Little information about their diagnosis and treatment, especially for adult ruminants is available and there are no predictors reported. In this experiment we will study the role of acute phase proteins (haptoglobin, serum amyloid A and fibrinogen), serum pepsinogen and plasma gastrin as possible predictors. The common goal for ulcer treatment is to reduce the gastric acid production using H2 receptor blocking agents or proton pump blockers. Ranitidine and omeprazole, are currently the most used drugs. The fact that for domestic adult ruminants no administration protocol has been established and that no proof of the efficacy of these drugs in mentioned situations is available makes this study necessary. Eighteen healthy adult male sheep with abomasal canulation will be used. The abomasal ulcer will be induced by administration of nonsteroidal anti-inflammatory drugs for up to twelve days. The animals will be distributed into three groups, whose treatments are: 2 mg / kg of ranitidine intravenously every twelve hours; 0.4 mg / kg of omeprazole intravenously once a day; and 4mg/kg of omeprazole orally once a day, until remission of abomasal mucosa injury. | |
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