| Grant number: | 14/00027-9 |
| Support Opportunities: | Scholarships abroad - Research |
| Start date: | May 12, 2014 |
| End date: | May 11, 2015 |
| Field of knowledge: | Biological Sciences - Microbiology - Applied Microbiology |
| Principal Investigator: | Edwin Tamashiro |
| Grantee: | Edwin Tamashiro |
| Host Investigator: | Jeffrey Neal Weiser |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Institution abroad: | University of Pennsylvania, United States |
Abstract In colonized niches, such as the gastrointestinal tract, commensal flora plays an important role in maintaining gastrointestinal homeostasis. However, little is known about the influence of commensal nasal flora on the pathogenesis of chronic inflammatory processes of the upper respiratory tract, such as chronic rhinosinusitis. A plausible hypothesis is that alterations in the resident flora may favor the colonization of pathogens and hence the emergence of chronic inflammation. Therefore, this study aims to elucidate whether the commensal flora interferes with the process of nasopharyngeal colonization of S. pneumoniae as well as possible mechanisms related to it. Using a murine animal model, we will evaluate if the depletion of commensal flora enhances pneumococcal colonization in the nasopharynx. If this occurs, we will evaluate possible mechanisms involved such as neutrophil recruitment, mucociliary transportation, stimulation of T helper responses and dependence on NOD1 and NOD2 receptors in these processes. The commensal flora will be eliminated by administration of broad spectrum antibiotics for ten days before inoculation of the nasal S. pneumoniae and will be compared to a control group. (AU) | |
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