| Grant number: | 13/23585-4 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | May 01, 2014 |
| End date: | August 31, 2017 |
| Field of knowledge: | Health Sciences - Physical Education |
| Principal Investigator: | Benedito Sérgio Denadai |
| Grantee: | Leonardo Coelho Rabello de Lima |
| Host Institution: | Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil |
| Associated scholarship(s): | 16/04909-1 - Effects of maximal isometric contractions of the knee extensors on muscle damage and running economy after Downhill running, BE.EP.DR |
Abstract Some longitudinal research models indicate that strength (maximal and explosive) might influence running economy (RE). However, other models [e.g., muscle damage (MD) induced by downhill running (DR)] show that the magnitude and the recovery kinetics of the RE and maximal strength measured by open kinetic chain (OKC) exercises [isometric peak torque (IPT)] might differ. Factors like the type of the exercise used to measures strength [OKC exercises vs. closed kinetic chain (CKC) exercises] and the manifestation of strength (maximal or explosive) can explain, at least in part, these confounding evidences. The general objective of this study is to use DR-induced MD as a model to analyze the relationship between maximal and explosive strength and RE. Firstly, the effects of DR-induced MD on RE and maximal and explosive strength (measured by OKC and CKC exercises) will be investigated. After this, 3 different study models will be applied to modulate DR-induced MD and check its effects on strength and RE. Healthy active subjects will be divided into control (CON), flavonoid supplementation (SUP), placebo (PLA), isometric (ISO) or combined (COMB) groups. Subjects on CON will be divided into individuals that express and don't express the ±-actinin-3 protein. All subjects will perform a 30-minute DR (-15%) at 70%VO2max. The SUP group will ingest a flavonoid rich supplement before and after the DR, PLA will consume a placebo, ISO group will perform 10 maximal isometric contractions two days prior to the DR and COMB will perform both supplementation and isometric contractions. MD markers (strength, soreness, range of motion, thigh circumference and creatine kinase seric activity) and RE markers will be assessed before, immediately after and 24, 48, 72 and 96 hours after the DR. Changes over time and between groups will be anylzed by two-way repeated measures ANOVAs (parametric data) and Friedman and Kurskal-Wallis tests (non-parametric data). | |
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