Anti-inflammatory response in atherosclerosis: identification and characterization of cytokines IL-27 and IL-37

• Grant number: 13/26808-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2014
• End date: February 29, 2016
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Maria Heloisa Souza Lima Blotta
• Grantee: Liana Maria Villarejos
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Atherosclerosis is a chronic inflammatory disease affecting the intima of the arteries and is the leading cause of cardiovascular disease, accounting for approximately 30% of annual deaths in Brazil. In atherosclerosis there is an imbalance between inflammatory and anti- inflammatory response which leads to the appearance of lesions and their complications. Several studies show the involvement of proinflammatory cytokines in atherosclerosis, however, the anti - inflammatory response in the disease is still poorly explored. Recent studies describe anti-inflammatory role of IL -27 and IL- 37 in chronic diseases like autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and uveitis. Both IL -27 for IL -37 are present in atherosclerotic lesions but its mechanism of action and role in disease have not been determined. Based on these data, this paper aims to study the involvement of IL - 27 and IL -37 in atherosclerosis by evaluating its expression (mRNA and protein) in atherosclerotic plaques and in peripheral blood mononuclear cells of patients with disease coronary artery and controls with and without risk factors for atherosclerosis. It will also be assessed IL- 27 and IL- 37 in monocyte-derived macrophages. Additionally, it is intended to evaluate the effect of these cytokines in the induction of proteases, chemokines and adhesion molecules by endothelial cells and smooth muscle cells are important components of the inflammatory response in atherosclerosis. The study of novel cytokines with anti - inflammatory potential as IL -27 and IL -37 may contribute to the better understanding of the process of control of the atherosclerotic process and suggest new avenues of intervention. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

VILLAREJOS, Liana Maria. Anti-inflammatory response in atherosclerosis: identification and characterization of the efect of IL-27 and IL-37. 2016. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.