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Salivary components and factors related to dental caries and periodontal disease in children with Down Syndrome

Grant number: 13/18010-2
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2014
Effective date (End): March 31, 2015
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Elisa Maria Aparecida Giro
Grantee:Natália Bertolo Domingues
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

People with Down Syndrome have low prevalence of caries and high prevalence of periodontal disease. The objective of this study is to evaluate salivary components and factors related to dental caries and periodontal disease in children with Down Syndrome and compare them with non-syndromic children. Forty six children aged 7-12 years, will be divided into two groups: DS - Down Syndrome (n=23) and NDS - Control Non-Syndromic (n=23). Intraoral examination will be performed in order to obtain CPO-D/ceo-d index and gingival index. Then, unstimulated whole saliva will be collected for a period of 5 minutes and salivary flow (mL/min) will be determined. The salivary pH and buffering capacity will be determined using a digital pHmeter. Streptococcus mutans, Lactobacillus spp. and Porphyromonas gingivalis counts will be determined by culture of saliva dilutions, using specific culture medium. Activity of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and total Antioxidant Capacity of Saliva (TAOC) will be quantified using specific colorimetric kits. The level of Malondialdehyde (MDA) will be quantified by HPLC method. The results will be analyzed by appropriate statistics tests, with a significance level of 5%. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMINGUES, NATALIA BERTOLO; MARIUSSO, MATHEUS RACY; TANAKA, MARCIA HIROMI; SCAREL-CAMINAGA, RAQUEL MANTUANELI; ALVES MAYER, MARCIA PINTO; BRIGHENTI, FERNANDA LOURENCAO; CILENSE ZUANON, ANGELA CRISTINA; IBUKI, FLAVIA KAZUE; NOGUEIRA, FERNANDO NEVES; APARECIDA GIRO, ELISA MARIA. Reduced salivary flow rate and high levels of oxidative stress in whole saliva of children with Down syndrome. SPECIAL CARE IN DENTISTRY, v. 37, n. 6, p. 269-276, NOV-DEC 2017. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DOMINGUES, Natália Bertolo. Fatores salivares relacion ados à cárie dentária e doença periodontal em crianças com síndrome de Down. 2015. 75 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Odontologia (Campus de Araraquara)..

Please report errors in scientific publications list by writing to: cdi@fapesp.br.