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Effects of simultaneous consumption of ethanol and caffeine on apoptosis in the cerebellum of UChB rats (voluntary ethanol consumers): Proteic analysis of Caspase 3, XIAP, and IGFR-1

Grant number: 14/06240-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal researcher:Marcelo Martinez
Grantee:Isabela Maria Urra Rossetto
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


The intake of energy drinks (with caffeine) simultaneously with the consumption of alcoholic beverages increases the risk of alcohol abuse and dependence, as it is associated with increased alcohol consumption both in quantity and frequency. The risks of this harmful intake and also the false perception that caffeine decrease the harmful effects of alcohol expose the youth and society to greater risks. Although the cerebellum constitutes only 10% of the total volume of the brain, contains more than half of all CNS neurons. Acts as coordinator of the motor part of cognition, development, and psychological disorders, possessing the thalamic connections to many brain areas relevant to these proceedings. There is a vast literature showing cerebellar lesions resulting from postnatal consumption of alcohol, but studies of the impact of alcohol on the adult are less frequent. On the other hand simultaneous analysis of the effects of ethanol and caffeine on cerebellar neurons are rare. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINEZ, M.; ROSSETTO, I. M. U.; ARANTES, R. M. S.; LIZARTE, F. S. N.; TIRAPELLI, L. F.; TIRAPELLI, D. P. C.; CHUFFA, L. G. A.; MARTINEZ, F. E. Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats. TOXICOLOGY RESEARCH, v. 8, n. 6, p. 842-849, NOV 1 2019. Web of Science Citations: 0.
MARTINEZ, MARCELO; ROSSETTO, ISABELA M. U.; LIZARTE NETO, FERMINO SANCHES; TIRAPELLI, LUIZ F.; TIRAPELLI, DANIELA P. C.; CHUFFA, LUIZ GUSTAVO A.; CAGNON, VALERIA H. A.; MARTINEZ, FRANCISCO E. Interactions of ethanol and caffeine on apoptosis in the rat cerebellum (voluntary ethanol consumers). Cell Biology International, v. 42, n. 11, p. 1575-1583, NOV 2018. Web of Science Citations: 3.

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