Effect of beta-hydroxybutyrate in mitochondrial function of isolated white adipocytes

• Grant number: 14/10705-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2014
• End date: August 31, 2018
• Field of knowledge: Biological Sciences - Physiology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Fabio Bessa Lima
• Grantee: Rennan de Oliveira Caminhotto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Among the ketones bodies, Beta- hydroxybutyrate (B-OH) is larger in quantity during ketogenesis, as well as possibilities of effects. The B-OH can activate membrane receptors, inhibit enzymes which control histone acetylation, induce intense formation of acetyl-CoA and energy for cellular metabolism. Data support the idea that the B-OH is signaling metabolite which influence metabolism and gene expression, including factors that regulate mitochondrial function. In this context, little is known about the direct effects of B-OH in physiological concentrations on the metabolism of white adipocytes different cushions, especially as regards mitochondrial biogenesis and thermogenic program. Thus, the central and initial objective of this work is to verify if the B-OH could regulate substrate oxidation in addition to markers of mitochondrial biogenesis and thermogenic program in white adipocytes from different fat pads. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMINHOTTO, RENNAN DE OLIVEIRA; TAVARES DA FONSECA, FELIPE LUCAS; DE CASTRO, NATALIE CAROLINA; ARANTES, JOAO PEDRO; LAURATO SERTIE, ROGERIO ANTONIO. Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 59, n. 6, p. 568-571, DEC 2015. (13/13601-2, 14/10705-4)

RENNAN DE OLIVEIRA CAMINHOTTO; FABIO BESSA LIMA. Low carbohydrate high fat diets: when models do not match reality. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 60, n. 4, p. -, Ago. 2016. (14/10705-4)

CAMINHOTTO, RENNAN DE OLIVEIRA; ANDREOTTI, SANDRA; MEDEIROS KOMINO, AYUMI CRISTINA; SILVA, FLAVIANE DE FATIMA; SERTIE, ROGERIO ANTONIO LAURATO; CHRISTOFFOLETE, MARCELO AUGUSTO; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Physiological concentrations of beta-hydroxybutyrate do not promote adipocyte browning. Life Sciences, v. 232, SEP 1 2019. (14/10705-4)

CAMINHOTTO, RENNAN DE OLIVEIRA; MEDEIROS KOMINO, AYUMI CRISTINA; SILVA, FLAVIANE DE FATIMA; ANDREOTTI, SANDRA; LAURATO SERTIE, ROGERIO ANTONIO; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Oral beta-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats. NUTRITION & METABOLISM, v. 14, APR 24 2017. (14/10705-4, 16/10218-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CAMINHOTTO, Rennan de Oliveira. Physiological concentrations of ketone bodies do not induce browning of white adipocytes/adipose tissue: in vitro and in vivo studies.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.