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Variability in Bothrops atrox snake venom from Western Pará: implications for snake ecology and pathophysiology of envenoming

Grant number: 14/13124-2
Support Opportunities:Scholarships in Brazil - Doctorate
Start date: October 01, 2014
End date: September 30, 2018
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Ana Maria Moura da Silva
Grantee:Leijiane Figueira de Sousa
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated scholarship(s):17/15170-0 - Characterization of mechanisms involved in the hemostatic disturbances induced by Bothrops atrox venoms from three locations of Brazilian Amazon, BE.EP.DR

Abstract

In Brazil, snake envenomings represent a major public health problem with a high incidence of in western Pará, mainly due to Bothrops atrox. Geographical variations in the composition of the venom from this species have been reported and may be an important factor for the adaptation of the snakes to different environments and may have implications for the clinical manifestations of envenoming in humans and efficacy of treatment by antivenom. However, environmental issues related to this variability have not yet been clarified. This question becomes even more relevant in western Pará because the richness of the ophidian fauna and the great anthropogenic pressure occurring in this region due to the ongoing spatial reorganization, which may interfere with the structure of ophidic communities. In this project, an accurate study of the composition of the venoms of B. atrox in the region will be performed, aiming to identify the components related to venom variability and relevant antigens for the production of more effective antivenoms. In this way, the variability in the composition of B. atrox venoms of geographically isolated populations (Santarém and Oriximiná) and populations of different floristic scenarios (forest, savanna and degraded areas) and also the individual variability within each population will be analyzed by proteomics. The components related to such variability will be characterized by mass spectrometry, by analysis of their pathophysiological activities and by reactivity with antivenoms. The results will be interpreted by their implications for the ecology of snakes and also for the clinical symptoms of envenoming and effectiveness of antivenom. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUSA, LEIJIANE F.; FREITAS, AMANDA P.; CARDOSO, BRUNA L.; DEL-REI, TIAGO H. M.; MENDES, VANESSA A.; OREFICE, DANIELE P.; ROCHA, MARISA M. T.; PREZOTO, BENEDITO C.; MOURA-DA-SILVA, ANA M.. Diversity of Phospholipases A(2) from Bothrops atrox Snake Venom: Adaptive Advantages for Snakes Compromising Treatments for Snakebite Patients. TOXINS, v. 14, n. 8, p. 24-pg., . (14/13124-2, 16/50127-5, 17/15170-0)
SOUSA, LEIJIANE F.; ZDENEK, CHRISTINA N.; DOBSON, JAMES S.; OP DEN BROUW, BIANCA; COIMBRA, FRANCISCO C. P.; GILLETT, AMBER; DEL-REI, TIAGO H. M.; CHALKIDIS, HIPOCRATES DE M.; SANT'ANNA, SAVIO; TEIXEIRA-DA-ROCHA, MARISA M.; et al. Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom Variation. TOXINS, v. 10, n. 10, . (14/13124-2, 17/15170-0, 17/50268-0)
SOUSA, LEIJIANE F.; BERNARDONI, JULIANA L.; ZDENEK, CHRISTINA N.; DOBSON, JAMES; COIMBRA, FRANCISCO; GILLETT, AMBER; LOPES-FERREIRA, MONICA; MOURA-DA-SILVA, A. M.; FRY, BRYAN G.. Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy. Toxicology Letters, v. 333, p. 211-221, . (12/23018-0, 17/15170-0, 14/13124-2)
AMAZONAS, DIANA R.; FREITAS-DE-SOUSA, LUCIANA A.; OREFICE, DANIELE P.; DE SOUSA, LEIJIANE F.; MARTINEZ, MELISSA G.; MOURAO, ROSA H. V.; CHALKIDIS, HIPOCRATES M.; CAMARGO, PLINIO B.; MOURA-DA-SILVA, ANA M.. Evidence for Snake Venom Plasticity in a Long-Term Study with Individual Captive Bothrops atrox. TOXINS, v. 11, n. 5, . (16/50127-5, 14/13124-2)
SOUSA, LEIJIANE F.; PORTES-JUNIOR, JOSE A.; NICOLAU, CAROLINA A.; BERNARDONI, JULIANA L.; NISHIYAMA-, JR., MILTON Y.; AMAZONAS, DIANA R.; FREITAS-DE-SOUSA, LUCIANA A.; MOURAO, ROSA H. V.; CHALKIDIS, HIPOCRATES M.; VALENTE, RICHARD H.; et al. Functional proteomic analyses of Bothrops atrox venom reveals phenotypes associated with habitat variation in the Amazon. JOURNAL OF PROTEOMICS, v. 159, p. 32-46, . (14/13124-2, 12/16277-9, 14/26058-8, 14/13592-6)
SOUSA, LEIJANE F.; HOLDING, MATTHEW L.; DEL-REI, TIAGO H. M.; ROCHA, MARISA M. T.; MOURAO, V, ROSA H.; CHALKIDIS, HIPOCRATES M.; PREZOTO, BENEDITO; GIBBS, H. LISLE; MOURA-DA-SILVA, ANA M.. Individual Variability in Bothrops atrox Snakes Collected from Different Habitats in the Brazilian Amazon: New Findings on Venom Composition and Functionality. TOXINS, v. 13, n. 11, . (17/15170-0, 16/50127-5, 14/13124-2)