Strength training and Raloxifene influence upon skeletal muscle and bone cells structure of senile rats

• Grant number: 14/04976-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2014
• End date: September 30, 2015
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Principal Investigator: Rita Cássia Menegati Dornelles
• Grantee: Laís Neves da Silva
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

During senescence occur several physiological changes, such as changes in plasma concentrations of sex steroids. In the female organism, this factor is compounded by menopause resulting in the decline of estrogen concentration, which exerts a strong influence on skeletal muscle tissue (SMT) . In addition, the strength training (ST), which is shown as an effective intervention in the management and prevention of muscle mass loss, estrogen hormone therapy (EHT) has been recommended. The EHT exerts a protective effect on the maintenance of lean body mass and muscle strength in women. However, the EHT effects are controversial. One negative effect of EHT is the incidence of neoplasms in tissues where estrogen exerts agonist action. Faced with this adverse effect, non-hormonal compounds of high affinity for estrogen receptors, selective estrogen receptor modulators (SERMs) have been developed. These exert antagonistic function of the mammary glands and the female reproductive organ. The SERM Raloxifene (RLX) inhibits osteoclastic resorptive activity, proving capable of inducing increased bone mass and reverse the osteopenic condition in senile rats. However, to date, the effects of RLX on the skeletal muscle cells structure are unknown. Therefore, this study aims to evaluate the effects of ST, treatment with RLX and their association over the muscle cells structure slow twitch (type I) and fast (type II ) in acyclic rats.