Modulation of hepatic expression of GPR120 receptor mediated physical exercise in obese rodents

• Grant number: 14/15258-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2014
• End date: January 31, 2016
• Field of knowledge: Health Sciences - Nutrition
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Dennys Esper Corrêa Cintra
• Grantee: Guilherme Pedron Formigari
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

Obesity is currently a condition absolutely out of control, where anti-inflammatory therapies or surgical procedures (bariatric surgery) are ineffective. Among the myriad of aggregated disease to obesity, type 2 diabetes (T2D) stands as the apex of uncontrolled metabolic disease. Meanwhile, changes in lifestyle thus remains to be the basic instrument. Chronic low-grade inflammation is the background for the metabolic disorder, in this context, the liver emerges as one of the main organs affected. In general, unsaturated fatty acids of the omega-3 series (w3) can help reverse the process, through its GPR120 receptor, which decouples the inflammatory process derived from Toll like receptors and TNF-±. Nevertheless, the physical exercise also impacts negatively on the progression of the inflammatory process. In this intention, this project aims to evaluate the effects of physical exercise coupled with nutrition, since physical activity seems to be able to modulate the expression of type receptors GPR120. Therefore, when using these two instruments in a coordinated manner, we may have to recover the metabolic process orchestrated by the liver more competently. Outcomes in physical exercise and Nutrigenomics in this study may perhaps open new types of strategies, even based on old science, nutrition and sport. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

GASPAR, RAFAEL CALAIS; VEIGA, CAMILLA BERTUZZO; BESSI, MARIANA PEREIRA; DATILO, MARCELLA NEVES; SANT'ANA, MARCELLA RAMOS; RODRIGUES, PATRICIA BRITO; DE MOURA, LEANDRO PEREIRA; RAMOS DA SILVA, ADELINO SANCHEZ; SANTOS, GUSTAVO APARECIDO; CATHARINO, RODRIGO RAMOS; et al. Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 66, p. 52-62, APR 2019. (14/15258-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FORMIGARI, Guilherme Pedron. The role of physical exercise and omega-3 fatty acids in the modulation of GPR120 expression in the liver of obese animals: the impact in the control of glucose homeostasis. 2016. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.