Effect of ischemic preconditioning on mechanisms that determine the aerobic performance in high level runners

• Grant number: 14/15877-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2014
• End date: July 31, 2016
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Bruno Moreira Silva
• Grantee: Jeann Luccas de Castro Sabino de Carvalho
• Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Federal de São Paulo (UNIFESP). São Paulo , SP, Brazil

Abstract

The resynthesis of adenosine triphosphate in mitochondria, upon oxygen consumption (VO2), is the predominant metabolic pathway of exercises involving dynamic contractions of large muscle groups performed by more than a few minutes (i.e, aerobic exercise). Thus, ergogenic methods with the potential to acutely improve oxidative metabolism are under intense scientific research. In this context, it is well established that Ischemic Preconditioning (IPC; brief cycles of ischemia) induces protection against acute myocardial infarction, which is attributed to mechanisms related to VO2, as mitochondrial function and micro-and macrovascular function. Moreover, it was recently shown that in addition to protection against infarction, PCI can also aerobic exercise performance. However, the mechanisms responsible for this effect are not known yet. Thus, this project aims to investigate the effect of PCI on the maximum oxygen consumption (VO2max), running economy, Lactate Threshold (LT) and the kinetics of VO2 increase in athletes with high aerobic capacity, because such mechanisms are well established as determinants of aerobic performance. Our hypotheses are that the IPC increases running economy, VO2max and exercise intensity where the LT occurs, besides decreases the slow component of increase in VO2 kinetics during aerobic exercise in the severe intensity domain. If these hypotheses are confirmed, the use of IPC can be employed as an ergogenic method to acutely improve the performance of athletes, whose sport involves a significant participation of aerobic exercise. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SABINO-CARVALHO, JEANN L.; LOPES, THIAGO R.; OBEID-FREITAS, TIAGO; FERREIRA, THIAGO N.; SUCCI, JOSE E.; SILVA, ANTONIO C.; SILVA, BRUNO M.. Effect of Ischemic Preconditioning on Endurance Performance Does Not Surpass Placebo. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 1, p. 124-132, JAN 2017. (14/15877-8, 15/03572-0, 14/24294-6)

SABINO-CARVALHO, JEANN L. C.; BARBOSA, THALES COELHO; SILVA, BRUNO MOREIRA. What is the effect of ischemic preconditioning on the kinetics of pulmonary oxygen uptake and muscle deoxygenation during exercise?. PHYSIOLOGICAL REPORTS, v. 3, n. 9, SEP 2015. (14/15877-8)

LOPES, THIAGO R.; SABINO-CARVALHO, JEANN L.; FERREIRA, THIAGO H. N.; SUCCI, JOSE E.; SILVA, ANTONIO C.; SILVA, BRUNO M.. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. FRONTIERS IN PHYSIOLOGY, v. 9, OCT 26 2018. (14/15877-8)

FERREIRA, THIAGO N.; SABINO-CARVALHO, JEANN L. C.; LOPES, THIAGO R.; RIBEIRO, INDYANARA C.; SUCCI, JOSE E.; DA SILVA, ANTONIO CARLOS; SILVA, BRUNO M.. Ischemic Preconditioning and Repeated Sprint Swimming: A Placebo and Nocebo Study. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 10, p. 1967-1975, OCT 2016. (14/15877-8, 15/03186-3)

SABINO-CARVALHO, JEANN L.; OBEID-FREITAS, TIAGO; PAULA-RIBEIRO, MARCELLE; LOPES, THIAGO R.; FERREIRA, THIAGO H. N.; SUCCI, JOSE E.; SILVA, ANTONIO C.; SILVA, BRUNO MOREIRA. Ischemic preconditioning boosts post-exercise but not resting cardiac vagal control in endurance runners. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 119, n. 3, p. 621-632, MAR 2019. (15/22198-2, 14/15877-8, 15/03572-0)

DE CASTRO SABINO-CARVALHO, JEANN LUCCAS; LOPES, THIAGO RIBEIRO; OBEID-FREITAS, TIAGO; NUNES FERREIRA, THIAGO HENRIQUE; SUCCI, JOSE ERNESTO; SILVA, ANTONIO CARLOS; SILVA, BRUNO MOREIRA. Acute Effect of Ischemic Preconditioning on VO(2)max and VO2 Kinetics at Supramaximal Intensity in High-Level Runners: A Randomized Placebo- and Nocebo-Controlled Study. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (14/15877-8, 15/03572-0)