Comparison of citotoxic effects of statins and putative protective effect of coenzyme Q10 in insulin secreting cells

• Grant number: 14/21351-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2014
• End date: January 31, 2015
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Helena Coutinho Franco de Oliveira
• Grantee: Isabele de Oliveira
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Recent findings and unpublished results from our group showed that statins are harmful for insulin secretion and may be diabetogenic. In this proposal we plan to compare the citotoxic effects of 5 different statins and test a potential protection of coenzyme Q10 in insulin secreting cells.