The role of the vesicles from T. cruzi vesicles in the interaction and invasion in the host cell

• Grant number: 14/12678-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2014
• End date: October 31, 2015
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Ana Claudia Trocoli Torrecilhas
• Grantee: João Henrique Coelho Campos
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Trypanosoma cruzi is capable to infect a variety of host cells. Recently, several studies have demonstrated the relationship of the released plasma membrane vesicles with various diseases such as cancer, thrombosis and parasitic infections. Results from our group showed that vesicles of T. cruzi released in the culture medium containing glycoconjugates are rich in ±-galactose epitopes, increase tissue parasitism and consequently, the response by macrophages and CD4 + T cells and inducing production IL-4 and IL-10. With the aim of better understanding the process of interaction and modulation of host response against the entry of T. cruzi, our project has as its main objective to analyze the release of these vesicles by T. cruzi isolates representing different degrees of virulence to check their invasion and interaction with the host cell. (AU)