Application of diazonium salts chemistry in structural modification of BODIPY fluorophores

• Grant number: 14/18973-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2014
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Pharmacy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Flavio da Silva Emery
• Grantee: Shaiani Maria Gil de Melo
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The BODIPYs (boron dypirromethene) are fluorescent compounds with a wide range of technological applications. These compounds have been highlighted in the literature in the photochemical and synthetic area. However, the chemical reactivity of these fluorophores are not fully understood. Therefore, we will study chemical reactivity of BODIPYs and develop a library of new fluorescent compounds. In this regard, we will use the chemistry of diazonium salts applied to BODIPYs, exploring a number of perspectives for structural diversification of these fluorophores. This strategy has not been applied to BODIPYs yet and has great potential for the development of compounds for chemical, biochemical and biological interest. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AMORIM, VANESSA G.; MELO, SHAIANI M. G.; LEITE, RUAN F.; COUTINHO, PAULO ARTHUR; DA SILVA, SARAH M. P.; DA SILVA, ANDRE R.; AMORIM, FERNANDA G.; PIRES, RITA G. W.; COITINHO, JULIANA B.; EMERY, FLAVIO S.; et al. Synthesis and characterization of two novel red-shifted isothiocyanate BODIPYs and their application in protein conjugation. DYES AND PIGMENTS, v. 182, NOV 2020. (14/18973-8, 13/24408-9, 11/23342-9)

REZENDE, LUCAS C. D.; MELO, SHAIANI M. G.; BOODTS, STIJN; VERBELEN, BRAM; EMERY, FLAVIO S.; DEHAEN, WIM. Thiocyanation of 3-substituted and 3,5-disubstituted BODIPYs and its application for the synthesis of new fluorescent sensors. DYES AND PIGMENTS, v. 154, p. 155-163, JUL 2018. (14/18973-8, 11/23342-9, 14/22451-7)

GIL DE MELO, SHAIANI MARIA; DIAS DE REZENDE, LUCAS CUNHA; PETRILLI, RAQUEL; VIANNA LOPEZ, RENATA FONSECA; GOULART, MARILIA O. F.; EMERY, FLAVIO DA SILVA. Nitrosation of BODIPY dyes and their applications in the development of thiol sensors. DYES AND PIGMENTS, v. 173, FEB 2020. (13/50677-7, 14/18973-8, 11/23342-9, 14/22451-7, 17/21146-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MELO, Shaiani Maria Gil de. Diazonium salts chemistry applied to BODIPY fluorophores. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.