Preparation and evaluation of monolithic silica-based modified with poly (dimethyl siloxane) (PDMS) for use in capillary liquid chromatography

• Grant number: 14/21866-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2014
• End date: November 30, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Carla Beatriz Grespan Bottoli
• Grantee: Fabiane Pires
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The aim of this project is to prepare, characterize and evaluate monolithic silica-based capillary columns, focusing on the process of immobilization of the polymer poly (dimethylsiloxane) (PDMS) on the silica monolith for application in capillary liquid chromatography. The preparation of monoliths will use the sol-gel process and the immobilization process of the polymer PDMS will be studied to optimize the conditions of solubilization, as well as the steps involved in the thermal immobilization: time, temperature and immobilization cycles, besides evaluation of the best extraction conditi ons. The characterization and evaluation of the monolithic columns will use scanning electron microscopy and several chromatographic parameters: retention factor (k), column efficiency calculated at half peak height (N), asymmetry factor at 10% of the peak height (As) and separation factor for adjacent peaks in test mixtures. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

PIRES, FABIANE; BAUTISTA OTALORA, JULIE ALEXANDRA; GRESPAN BOTTOLI, CARLA BEATRIZ. New stationary phase for capillary liquid chromatography based on polydimethylsiloxane immobilized onto a Monolithic Silica Support. SEPARATION SCIENCE PLUS, v. 1, n. 5, p. 343-350, MAY 2018. (14/21866-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PIRES, Fabiane. Preparation and evaluation of monolithic capillary columns based on silica modified with polydimethylsiloxane (PDMS) for use in capillary liquid chromatography. 2017. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.