Evaluation of efficiency of flavonoids and non steroidal antiinflammatory over the inhibition of cyclooxygenases (COX-2) by the preparation of hematin biomimetic sensors

• Grant number: 14/21924-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2015
• End date: May 15, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Silvia Helena Pires Serrano
• Grantee: Rafael Martos Buoro
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Inflammatory processes are present in neurodegenerative diseases such as Alzheimer's disease , cancer and autoimmune diseases whose treatment is the administration of non-steroidal antiinflammatories and flavonoids to the patient. The project aims to characterize the electrochemical behavior of active and potentially bioavailable flavonoids , and their action as inhibitors of the enzyme COX- 2 . (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUORO, RAFAEL M.; CAMPOS, OTHON S.; BACIL, RAPHAEL P.; SERRANO, SILVIA H. P.. Insights toward the Electrochemical Behavior of Hematin Using a Hematin Modified Glassy Carbon Electrode. Journal of the Electrochemical Society, v. 163, n. 10, p. G178-G185, 2016. (14/21924-9)

BUORO, RAFAEL M.; BACIL, RAPHAEL P.; SANZ, CAROLINE G.; CAMPOS, OTHON S.; SERRANO, SILVIA H. P.. Biomimetic behavior and nanomolar detection of hydrogen peroxide on an electrochemically pre-treated hematin modified glassy carbon electrode. SENSORS AND ACTUATORS B-CHEMICAL, v. 250, p. 169-178, OCT 2017. (14/21924-9)